Molecular pathogenesis of the Antiphospholipid syndrome

被引：94
|
作者：
Rand, JH [1 ]
机构：
[1] Mt Sinai Sch Med, Div Hematol, Dept Med, Thrombosis & Hemostasis Sect, New York, NY 10029 USA
来源：
CIRCULATION RESEARCH | 2002年 / 90卷 / 01期
关键词：
antiphospholipid antibodies; anticardiolipin antibodies; lupus anticoagulants; thrombosis; annexins;
D O I：
10.1161/hh0102.102795
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The antiphospholipid (aPL) syndrome is an acquired autoimmune disorder of unknown etiology in which patients present with thrombosis together with laboratory evidence for antibodies in blood that recognize anionic phospholipid-protein complexes. The main antigenic target for the aPL antibodies has been identified to be beta(2) glycoprotein I (beta(2)GPI), a phospholipid-binding protein. The high affinity of aPL antibody-beta(2)GPI complex for phospholipid membranes seems to be a critical step in the mechanism of this disease. This review focuses on some of the major mechanisms that have been proposed to explain this disorder.
引用
收藏
页码：29 / 37
页数：9
相关论文
共 50 条
  • [21] Pathogenesis of antiphospholipid syndrome: understanding the antibodies
    Meroni, Pier Luigi
    Borghi, M. Orietta
    Raschi, Elena
    Tedesco, Francesco
    [J]. NATURE REVIEWS RHEUMATOLOGY, 2011, 7 (06) : 330 - 339
  • [22] Insights into the diagnosis and pathogenesis of the antiphospholipid syndrome
    Noureldine, Mohammad Hassan A.
    Nour-Eldine, Wared
    Khamashta, Munther A.
    Uthman, Imad
    [J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 2019, 48 (05) : 860 - 866
  • [23] The antiphospholipid syndrome and atherosclerosis: Clue to pathogenesis
    Joan T. Merrill
    [J]. Current Rheumatology Reports, 2003, 5 (5) : 401 - 406
  • [24] Pathogenesis and treatment of the antiphospholipid antibody syndrome
    Petri, M
    [J]. MEDICAL CLINICS OF NORTH AMERICA, 1997, 81 (01) : 151 - +
  • [25] Update on the pathogenesis and treatment of the antiphospholipid syndrome
    Chighizola, Cecilia Beatrice
    Raschi, Elena
    Borghi, M. Orietta
    Meroni, Pier Luigi
    [J]. CURRENT OPINION IN RHEUMATOLOGY, 2015, 27 (05) : 476 - 482
  • [26] Pathogenesis of antiphospholipid syndrome: understanding the antibodies
    Pier Luigi Meroni
    M. Orietta Borghi
    Elena Raschi
    Francesco Tedesco
    [J]. Nature Reviews Rheumatology, 2011, 7 : 330 - 339
  • [27] THE ANTIPHOSPHOLIPID SYNDROME - DIAGNOSIS, MANAGEMENT, AND PATHOGENESIS
    HARRIS, EN
    [J]. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 1995, 13 (01) : 39 - 48
  • [28] INDUCTION AND PATHOGENESIS OF ANTIPHOSPHOLIPID ANTIBODY (APA) SYNDROME
    GILMANSACHS, A
    WONG, D
    WESTERMAN, MP
    KUCUK, O
    BEAMAN, KD
    [J]. JOURNAL OF IMMUNOLOGY, 1993, 150 (08): : A72 - A72
  • [29] Antiphospholipid Syndrome and the Neurologist: From Pathogenesis to Therapy
    Fleetwood, Thomas
    Cantello, Roberto
    Comi, Cristoforo
    [J]. FRONTIERS IN NEUROLOGY, 2018, 9
  • [30] The Role of the Gut Microbiota in the Pathogenesis of Antiphospholipid Syndrome
    Ruff, William E.
    Vieira, Silvio M.
    Kriegel, Martin A.
    [J]. CURRENT RHEUMATOLOGY REPORTS, 2015, 17 (01)
12345