Highly enantioselective copper-phosphoramidite-catalyzed conjugate addition of dialkylzinc reagents to acyclic α,β-unsaturated imides

被引：25

作者：

Pineschi, M ^{[1
]}

Del Moro, F ^{[1
]}

Di Bussolo, V ^{[1
]}

Macchia, F ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim Bioorgan & Biofarm, I-56126 Pisa, Italy

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 03期

关键词：

asymmetric catalysis; C-C bond formation; conjugate addition; copper; phosphoramidite ligands; zinc;

D O I：

10.1002/adsc.200505309

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new and practical way to introduce an alkyl fragment in the beta-position of aliphatic carboxylic acid derivatives with high enantioselectivities by the use of a commercially available chiral ligand is reported. N-Acylpyrrolidinones, as simple derivatives of an alpha,beta-unsaturated carboxylic acid, were found to be the substrates of choice featuring good reactivity and high en antioselectivities (up to > 99% ee).

引用

页码：301 / 304

页数：4

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