Highly enantioselective copper-phosphoramidite-catalyzed conjugate addition of dialkylzinc reagents to acyclic α,β-unsaturated imides

被引：25
|
作者：
Pineschi, M [1 ]
Del Moro, F [1 ]
Di Bussolo, V [1 ]
Macchia, F [1 ]
机构：
[1] Univ Pisa, Dipartimento Chim Bioorgan & Biofarm, I-56126 Pisa, Italy
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 03期
关键词：
asymmetric catalysis; C-C bond formation; conjugate addition; copper; phosphoramidite ligands; zinc;
D O I：
10.1002/adsc.200505309
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new and practical way to introduce an alkyl fragment in the beta-position of aliphatic carboxylic acid derivatives with high enantioselectivities by the use of a commercially available chiral ligand is reported. N-Acylpyrrolidinones, as simple derivatives of an alpha,beta-unsaturated carboxylic acid, were found to be the substrates of choice featuring good reactivity and high en antioselectivities (up to > 99% ee).
引用
收藏
页码：301 / 304
页数：4
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