Discovery and in vivo activity of sphingosine kinase 2 selective inhibitors

被引：0
|
作者：
Santos, Webster L. [1 ]
Raje, Mithun [1 ]
Knott, Kenneth [1 ]
Kharel, Yugesh [2 ]
Lynch, Kevin R. [2 ]
Gao, Ming [1 ]
机构：
[1] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA
[2] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 244卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
26-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Structure-Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors
    Baek, Dong Jae
    MacRitchie, Neil
    Anthony, Nahoum G.
    Mackay, Simon P.
    Pyne, Susan
    Pyne, Nigel J.
    Bittman, Robert
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (22) : 9310 - 9327
  • [42] Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors
    Congdon, Molly D.
    Childress, Elizabeth S.
    Patwardhan, Neeraj N.
    Gumkowski, James
    Morris, Emily A.
    Kharel, Yugesh
    Lynch, Kevin R.
    Santos, Webster L.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (21) : 4956 - 4960
  • [43] Design, synthesis, antitumor activity, and molecular dynamics simulations of novel sphingosine kinase 2 inhibitors
    Wang, ShaSha
    Huo, Yidan
    Zhang, Jinmiao
    Li, Longfei
    Cao, Fei
    Song, Yali
    Zhang, Yajing
    Yang, Kan
    BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 93
  • [44] Discovery of Potent and Highly Selective Interleukin-2-Inducible T-Cell Kinase Degraders with In Vivo Activity
    Zhou, Danli
    Zuo, Yingying
    Pan, Zhengying
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (07) : 4979 - 4998
  • [45] Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity
    Leger, Paul R.
    Hu, Dennis X.
    Biannic, Berenger
    Bui, Minna
    Han, Xinping
    Karbarz, Emily
    Maung, Jack
    Okano, Akinori
    Osipov, Maksim
    Shibuya, Grant M.
    Young, Kyle
    Higgs, Christopher
    Abraham, Betty
    Bradford, Delia
    Cho, Cynthia
    Colas, Christophe
    Jacobson, Scott
    Ohol, Yamini M.
    Pookot, Deepa
    Rana, Payal
    Sanchez, Jerick
    Shah, Niket
    Sun, Michael
    Wong, Steve
    Brockstedt, Dirk G.
    Kassner, Paul D.
    Schwarz, Jacob B.
    Wustrow, David J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (10) : 5398 - 5420
  • [46] Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2
    French, Kevin J.
    Zhuang, Yan
    Maines, Lynn W.
    Gao, Peng
    Wang, Wenxue
    Beljanski, Vladimir
    Upson, John J.
    Green, Cecelia L.
    Keller, Staci N.
    Smith, Charles D.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 333 (01): : 129 - 139
  • [47] Design and discovery of new selective and potent VEGF receptor 2 tyrosine kinase inhibitors
    Hou, Fei
    Yao, Yuhong
    Wei, Yujiao
    Wang, Yubo
    Cao, Yangzi
    Liu, Xinqiang
    Zheng, Liting
    Zhang, Qingqing
    Jiao, Yue
    Chen, Yukun
    Meng, Yue
    Sun, Yue
    Wu, Yanjie
    Wang, Jiefu
    Wang, Junfeng
    Wu, Zhou
    Zhang, Kun
    Wei, Mingming
    Yang, Guang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 91
  • [48] Recent discovery and development of selective protein kinase C inhibitors
    Hu, H
    DRUG DISCOVERY TODAY, 1996, 1 (10) : 438 - 447
  • [49] Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
    Pan, Zhengying
    Scheerens, Heleen
    Li, Shyr-Jiann
    Schultz, Brian E.
    Sprengeler, Paul A.
    Burrill, L. Chuck
    Mendonca, Rohan V.
    Sweeney, Michael D.
    Scott, Keana C. K.
    Grothaus, Paul G.
    Jeffery, Douglas A.
    Spoerke, Jill M.
    Honigberg, Lee A.
    Young, Peter R.
    Dalrymple, Stacie A.
    Palmer, James T.
    CHEMMEDCHEM, 2007, 2 (01) : 58 - 61
  • [50] Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia
    Vagadia, Purav P.
    Izquierdo-Ferrer, Javier
    Mazewski, Candice
    Blyth, Gavin
    Beauchamp, Elspeth M.
    Clutter, Matthew R.
    Stern, Charlotte L.
    Mishra, Rama K.
    Nahotko, Dominik
    Small, Sara
    Eckerdt, Frank
    Platanias, Leonidas C.
    Schiltz, Gary E.
    JOURNAL OF MEDICINAL CHEMISTRY, 2025, 68 (05) : 5824 - 5844
12345