A four-step scalable formal synthesis of ningalin C

被引：8

作者：

Ramadoss, Velayudham ^{[1
]}

Nahide, Pradip D. ^{[1
]}

Juarez-Ornelas, Kevin A. ^{[1
]}

Renteria-Gomez, Marvin ^{[1
]}

Ortiz-Alvarado, Rafael ^{[2
]}

Solorio-Alvarado, Cesar R. ^{[1
]}

机构：

[1] Univ Guanajuato, Div Ciencias Nat & Exactas, Dept Quim, Campus Guanajuato,Cerro Venada S-N, Guanajuato 36040, Gto, Mexico

[2] Univ Michoacana, Fac Quim Farmacobiol, Tzintzuntzan 173, Morelia 58240, Michoacan, Mexico

来源：

ARKIVOC | 2016年

关键词：

Ningalin C; formal synthesis; squaric esters; RESISTANCE REVERSAL ACTIVITY; ALKALOIDS; POLYCITRIN;

D O I：

10.3998/ark.5550190.p009.631

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical, concise and scalable synthesis of a key intermediate in the preparation of the alkaloid ningalin C was developed over four steps in 29% overall yield. The procedure involves three commercially available starting materials and uses the chemistry of squaric esters. In view of the relevance of scalability in recent times, herein is highlighted the importance of the developed strategy, allowing the preparation of close to 300 mg of the key quinone.

引用

页码：385 / 395

页数：11

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