Solvent-Free Microwave Assisted Synthesis of Novel Pyrazole-Oxopyrrolidine and Pyrazole-Oxopiperidine Derivatives and Their Antimicrobial Activity

被引：6
|
作者：
Jassem, A. M. [1 ]
Almashal, F. A. K. [1 ]
Jaber, H. A. S. [1 ]
机构：
[1] Basrah Univ, Coll Educ Pure Sci, Dept Chem, Basrah 61004, Iraq
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 05期
关键词：
solvent-free synthesis; microwave; antimicrobial activity; pyrazole-oxopyrrolidine derivatives; IN-VITRO;
D O I：
10.1134/S1070363220050230
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein we report an efficient one-pot multicomponent synthesis of novel pyrazole-oxopyrrolidine derivatives via the Ugi (4C3C) reaction under MW solvent-free conditions. The structures of products have been characterized by FTIR,H-1 and(13)C NMR, and mass spectrometry, and HPLC analysis. All synthesized compounds have been tested for their antimicrobial activity and some of those characterized as highly active.
引用
收藏
页码：895 / 900
页数：6
相关论文
共 50 条
  • [41] Synthesis of polyfunctional pyridazine derivatives using a solvent-free microwave assisted method
    Sotelo, Eddy
    Mocelo, Raúl
    Suárez, Margarita
    Loupy, André
    Bellwether Publishing, Ltd. (27):
  • [42] Synthesis of Polyfunctional Pyridazine Derivatives Using a Solvent-Free Microwave Assisted Method
    Sotelo, E.
    Mocelo, R.
    Suarez, M.
    Loupy, A.
    Synthetic Communications, 27 (14):
  • [43] Microwave Assisted Synthesis and Antimicrobial Activity of Novel Pyrrolidine Derivatives
    Sreekanth, K.
    Jha, Anjali
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2020, 90 (01) : 129 - 134
  • [44] Microwave Assisted Synthesis and Antimicrobial Activity of Novel Pyrrolidine Derivatives
    K. Sreekanth
    Anjali Jha
    Russian Journal of General Chemistry, 2020, 90 : 129 - 134
  • [45] Microwave Assisted Solvent-Free Synthesis of Novel Chenodeoxycholic Acid Thiosemicarbazone Derivatives and Studies on Antibacterial Activities
    Zhao, Zhi-Gang
    Yan, Ping
    Liu, Xing-Li
    Shi, Zhi-Chuan
    LETTERS IN ORGANIC CHEMISTRY, 2012, 9 (08) : 604 - 608
  • [46] Novel pyrazole-5-carboxamide and pyrazole-pyrimidine derivatives: Synthesis and anticancer activity
    Shi, Jing Bo
    Tang, Wen Jian
    Qi, Xing Bao
    Li, Rong
    Liu, Xin Hua
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 90 : 889 - 896
  • [47] Synthesis and characterization of selected fused isoxazole and pyrazole derivatives and their antimicrobial activity
    Dabholkar, Vijay V.
    Ansari, Faisal Y.
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2009, 74 (11) : 1219 - 1228
  • [48] Synthesis of Pyrano, Pyrido, Oxazino, and Spiro Pyrazole Derivatives and Their Antimicrobial Activity
    E. F. Abdelrahman
    W. Shehta
    M. G. M. Assy
    M. E. Farhan
    Russian Journal of Organic Chemistry, 2020, 56 : 1832 - 1839
  • [49] A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole
    Sarma, K. Narasimha
    Subha, M. C. S.
    Rao, K. Chowdoji
    E-JOURNAL OF CHEMISTRY, 2010, 7 (03) : 745 - 750
  • [50] Synthesis of Pyrano, Pyrido, Oxazino, and Spiro Pyrazole Derivatives and Their Antimicrobial Activity
    Abdelrahman, E. F.
    Shehta, W.
    Assy, M. G. M.
    Farhan, M. E.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (10) : 1832 - 1839
12345