Synthesis and antibacterial activity of some new hydrazones

被引：20

作者：

Rudrapal, M. ^{[1
]}

Satyanandam, R. Siva ^{[1
]}

Swaroopini, T. Sri ^{[1
]}

Lakshmi, T. Naga ^{[1
]}

Jaha, S. Kamar ^{[1
]}

Zaheera, S. ^{[1
]}

机构：

[1] Aditya Inst Pharmaceut Sci & Res, Surampalem 533437, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 06期

关键词：

Hydrazone; Azomethine; Heteroaromatic scaffold; Antibacterial; DERIVATIVES;

D O I：

10.1007/s00044-012-0278-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New hydrazone derivatives were synthesized by the condensation of some selected heteroaromatic hydrazines with appropriate aromatic ketones at high temperature (100 A degrees C). The structures of the synthesized compounds were established by elemental (CHN) and spectral (IR, (HNMR)-H-1, and Mass) analysis. The synthesized compounds were screened for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Proteus mirabilis) activities, which reveal that all the compounds possess activity against all the tested organisms.

引用

页码：2840 / 2846

页数：7

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