RHODIUM-CATALYZED SYNTHESIS OF BENZOFURANS BY THE REACTION OF KETONES AND O-DIFLUOROBENZENES

被引：5

作者：

Arisawa, Mieko ^{[1
]}

Nakane, Soichiro ^{[1
]}

Kuwajima, Manabu ^{[1
]}

Yamaguchi, Masahiko ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Organ Chem, Sendai, Miyagi 9808578, Japan

来源：

HETEROCYCLES | 2012年 / 86卷 / 02期

关键词：

Benzofuran; o-Difluorobenzene; Polyfluorinated Benzofuran; Rhodium-Catalyzed Reaction; alpha-Arylation; ONE-POT SYNTHESIS; ALPHA-ARYLATION; INHIBITORS; OLIGOSTILBENES; DERIVATIVES; CHEMISTRY;

D O I：

10.3987/COM-12-S(N)57

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of catalytic amounts of RhH(PPh3)(4) and 1,2-bis(diphenylphosphino)ethane (dppe), ketones reacted with o-difluorobenzenes giving benzofurans in high yields. The alpha-arylation of ketones and furan cyclization proceeded without using a base. Benzofuran cyclization was applied to substituted pentafluorobenzenes to give 6-substituted-4,5,7-trifluorobenzofuranes.

引用

页码：1103 / 1118

页数：16

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