Biotherapeutic Products, Cellular Factories, and Multiomics Integration in Metabolic Engineering

被引：1

作者：

Hoang Anh, Nguyen ^{[1
]}

Min, Jung Eun ^{[1
]}

Kim, Sun Jo ^{[1
]}

Phuoc Long, Nguyen ^{[2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 08826, South Korea

来源：

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY | 2020年 / 24卷 / 11期

关键词：

biotherapeutics; metabolic engineering; metabolomics; multiomics; artificial intelligence; machine learning; ELECTROPHORESIS-MASS SPECTROMETRY; CAPILLARY-ELECTROPHORESIS; CE-MS; MONOCLONAL-ANTIBODIES; CHO-CELLS; FED-BATCH; THERAPEUTIC ANTIBODIES; SYSTEMATIC-APPROACH; CULTURE PROCESSES; NEXT-GENERATION;

D O I：

10.1089/omi.2020.0112

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Since the introduction of the first monoclonal antibody, biopharmaceuticals and biotherapeutic products manufactured in cellular factories are on the rise in modern medicine and therapeutics. Dynamic and real-time innovation strategies for operational implementation of biotherapeutic production are rapidly emerging. The advances in related fields such as genome editing technology, systems biology, and machine learning/artificial intelligence are expected to introduce innovative solutions in every aspect of the mammalian cell culture-based biotherapeutic production. This conceptual review offers a synthesis of the prospects and challenges of integration of multiomics technologies, and an integrative biology vision to cellular factories and biotherapeutic innovation.

引用

页码：621 / 633

页数：13

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