Engineering microbial factories for synthesis of value-added products

被引：166

作者：

Du, Jing ^{[3
]}

Shao, Zengyi ^{[3
]}

Zhao, Huimin ^{[1
,2
,3
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Biochem, Inst Genom Biol, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2011年 / 38卷 / 08期

基金：

新加坡国家研究基金会; 美国国家科学基金会; 美国国家卫生研究院;

关键词：

Synthetic biology; Metabolic engineering; Microbial synthesis; Value-added products; Natural products; Fuels and chemicals; RECOMBINANT ESCHERICHIA-COLI; UTILIZING SACCHAROMYCES-CEREVISIAE; MYCOPLASMA-GENITALIUM GENOME; ANTIMALARIAL-DRUG PRECURSOR; SUCCINIC ACID PRODUCTION; COMBINATORIAL BIOSYNTHESIS; BENZYLISOQUINOLINE ALKALOIDS; 3-HYDROXYPROPIONIC ACID; POLYKETIDE BIOSYNTHESIS; SECONDARY METABOLITES;

D O I：

10.1007/s10295-011-0970-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microorganisms have become an increasingly important platform for the production of drugs, chemicals, and biofuels from renewable resources. Advances in protein engineering, metabolic engineering, and synthetic biology enable redesigning microbial cellular networks and fine-tuning physiological capabilities, thus generating industrially viable strains for the production of natural and unnatural value-added compounds. In this review, we describe the recent progress on engineering microbial factories for synthesis of valued-added products including alkaloids, terpenoids, flavonoids, polyketides, non-ribosomal peptides, biofuels, and chemicals. Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed.

引用

页码：873 / 890

页数：18

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