Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

被引：3

作者：

Stuart, Darrin D. ^{[1
]}

Shao, Wenlin ^{[1
]}

Mishina, Yuji ^{[1
]}

Feng, Yun ^{[1
]}

Caponigro, Giordano ^{[1
]}

Cooke, Vesselina G. ^{[1
]}

Rivera, Stacey ^{[1
]}

Shen, Fang ^{[1
]}

Korn, Joshua ^{[1
]}

Griner, Lesley A. Mathews ^{[1
]}

Nishiguchi, Giselle ^{[1
]}

Taft, Benjamin ^{[2
]}

Wan, Lifeng ^{[2
]}

Subramanian, Sharadha ^{[2
]}

Lou, Yan ^{[2
]}

Setti, Lina ^{[2
]}

Burger, Matthew ^{[1
]}

Tamez, Victor ^{[1
]}

Rico, Alice ^{[2
]}

Aversa, Robert ^{[1
]}

Tellew, John ^{[3
]}

Haling, Jacob R. ^{[3
]}

Polyakov, Valery ^{[2
]}

Lambert, Amy ^{[1
]}

Zang, Richard ^{[2
]}

Van Abbema, Ann ^{[2
]}

Hekmat-Nejad, Mohamad ^{[2
]}

Amiri, Payman ^{[2
]}

Singh, Mallika ^{[2
]}

Keen, Nicholas ^{[1
]}

Dillon, Michael P. ^{[2
]}

Lees, Emma ^{[1
]}

Sellers, William R. ^{[1
]}

Ramurthy, Savithri ^{[2
]}

机构：

[1] Novartis Inst Biomed Res, Cambridge, MA USA

[2] Novartis Inst Biomed Res, Emveryville, CA USA

[3] Novartis Res Fdn, Genom Inst, San Diego, CA USA

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2018-DDT01-04

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DDT01-04

引用

页数：2

共 50 条

[41] Preclinical development of a novel oral multitargeted kinase inhibitor with potent in vivo anti-tumor activity
Beaulieu, Normand
Dupont, Isabelle
Hannah Nguyen
Carole, Beaulieu
Ste-Croix, Helene
Robert, Marie-France
Lefebvre, Sylvain
Lu, Ai Hua
Dubay, Maria
Rahil, Gabi
Wang, James
Mannion, Michael
Raeppel, Stephane
Saavedra, Oscar
Claridge, Stephen
Isakovic, Lubo
Zhan, Lijie
Gaudette, Frederic
Zhou, Nancy
Nantel, Miguel
Raeppel, Franck
Vaisburg, Arkadii
Besterman, Jeffrey
Maroun, Christiane
CANCER RESEARCH, 2009, 69
[42] Broad-based anti-tumor activity of the Aurora A kinase inhibitor, MLN8054.
Zhang, MK
Burenkova, O
Chandra, S
Connolly, K
Huck, J
Manfredi, MG
Saylor, M
Zhang, YM
Meetze, KA
CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9082S - 9082S
[43] Anti-Tumor Effects of Wee1 Kinase Inhibitor with Radiotherapy in Human Cervical Cancer
Yoo-Young Lee
Young-Jae Cho
Sung-won Shin
Changhoon Choi
Ji-Yoon Ryu
Hye-Kyung Jeon
Jung-Joo Choi
Jae Ryoung Hwang
Chel Hun Choi
Tae-Joong Kim
Byoung- Gie Kim
Duk-Soo Bae
Won Park
Jeong-Won Lee
Scientific Reports, 9
[44] Battling Glioblastoma: A Novel Tyrosine Kinase Inhibitor with Multi-Dimensional Anti-Tumor Effect
Viswanathan, Anisha
Musa, Aliyu
Murugesan, Akshaya
Vale, Joao R.
Afonso, Carlos A. M.
Mani, Saravanan Konda
Yli-Harja, Olli
Candeias, Nuno R.
Kandhavelu, Meenakshisundaram
CELLS, 2019, 8 (12)
[45] Anti-Tumor Effects of Wee1 Kinase Inhibitor with Radiotherapy in Human Cervical Cancer
Lee, Yoo-Young
Cho, Young-Jae
Shin, Sung-won
Choi, Changhoon
Ryu, Ji-Yoon
Jeon, Hye-Kyung
Choi, Jung-Joo
Hwang, Jae Ryoung
Choi, Chel Hun
Kim, Tae-Joong
Kim, Byoung-Gie
Bae, Duk-Soo
Park, Won
Lee, Jeong-Won
SCIENTIFIC REPORTS, 2019, 9 (1)
[46] Pharmacological profile of KR-33028, a highly selective inhibitor of Na+/H+ exchanger
Jung, YS
Kim, MY
Kim, MJ
Oh, KS
Yi, KY
Lee, S
Yoo, S
Lee, BH
EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 535 (1-3) : 220 - 227
[47] Diaminothiazoles: Potent, selective cyclin-dependent kinase inhibitors with anti-tumor efficacy.
Lundgren, K
Price, SM
Escobar, J
Huber, A
Chong, W
Li, L
Duvadie, R
Chu, SS
Yang, Y
Nonomiya, J
Tucker, K
Knighton, D
Ferre, R
Lewis, C
CLINICAL CANCER RESEARCH, 1999, 5 : 3755S - 3755S
[48] Q901; a highly selective covalent cdk7 inhibitor inducing substantial anti-tumor effect in a broad spectrum of solid tumor lineages
Yu, Donghoon
Jeon, Yeejin
Lee, Seung-Joo
Kim, Jaeseung
Nam, Kiyean
CANCER RESEARCH, 2022, 82 (12)
[49] Discovery of a potent, highly selective, and efficacious RAF kinase inhibitor to treat non-small lung cancers (NSCLC)
Ramurthy, Savithri
Nishiguchi, Gisele
Rico, Alice
Taft, Benjamin
Aversa, Robert
Barsanti, Paul
Briner, Karin
Burger, Matthew
Dillon, Michael
Dineen, Thomas
Ginn, Elaine
Jansen, Johanna
Lou, Yan
Mamo, Mulugeta
Polyakov, Valery
Rauniyar, Vivek
Subramanian, Sharadha
Tanner, Huw
Wan, Lifeng
Appleton, Brent
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
[50] Anti-tumor Activity of the PLK Inhibitor Volasertib (BI 6727) and the Aurora Kinase Inhibitor BI 811283 in Pediatric Malignancies
Lanvers-Kaminsky, C.
Abbou, S.
Daudigeos-Dubus, E.
Molenaar, J.
Verschuur, A.
Caron, H.
Vassal, G.
Geoerger, B.
EUROPEAN JOURNAL OF CANCER, 2012, 48 : 78 - 78

← 1 2 3 4 5 →