Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

被引：3

作者：

Stuart, Darrin D. ^{[1
]}

Shao, Wenlin ^{[1
]}

Mishina, Yuji ^{[1
]}

Feng, Yun ^{[1
]}

Caponigro, Giordano ^{[1
]}

Cooke, Vesselina G. ^{[1
]}

Rivera, Stacey ^{[1
]}

Shen, Fang ^{[1
]}

Korn, Joshua ^{[1
]}

Griner, Lesley A. Mathews ^{[1
]}

Nishiguchi, Giselle ^{[1
]}

Taft, Benjamin ^{[2
]}

Wan, Lifeng ^{[2
]}

Subramanian, Sharadha ^{[2
]}

Lou, Yan ^{[2
]}

Setti, Lina ^{[2
]}

Burger, Matthew ^{[1
]}

Tamez, Victor ^{[1
]}

Rico, Alice ^{[2
]}

Aversa, Robert ^{[1
]}

Tellew, John ^{[3
]}

Haling, Jacob R. ^{[3
]}

Polyakov, Valery ^{[2
]}

Lambert, Amy ^{[1
]}

Zang, Richard ^{[2
]}

Van Abbema, Ann ^{[2
]}

Hekmat-Nejad, Mohamad ^{[2
]}

Amiri, Payman ^{[2
]}

Singh, Mallika ^{[2
]}

Keen, Nicholas ^{[1
]}

Dillon, Michael P. ^{[2
]}

Lees, Emma ^{[1
]}

Sellers, William R. ^{[1
]}

Ramurthy, Savithri ^{[2
]}

机构：

[1] Novartis Inst Biomed Res, Cambridge, MA USA

[2] Novartis Inst Biomed Res, Emveryville, CA USA

[3] Novartis Res Fdn, Genom Inst, San Diego, CA USA

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2018-DDT01-04

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DDT01-04

引用

页数：2

共 50 条

[31] An oral and selective CDK12 inhibitor demonstrates robust anti-tumor activity
Hu, Shanhu
Moebius, David
Dworakowski, Wojciech
Cooper, Elliott
LaPlaca, Derek
Alnemy, Sydney
Perera, Phone
Marineau, Jason
Chuaqui, Claudio
Carulli, John P.
Olson, Eric
CANCER RESEARCH, 2022, 82 (12)
[32] Sustained proteasome inhibition by carfilzomib, a selective proteasome inhibitor, enhances anti-tumor activity
Aujay, Monette
Demo, Susan
Jiang, Jing
Kirk, Christopher
Parlati, Francesco
Suzuki, Erika
Woo, Tina
Bennett, Mark
CANCER RESEARCH, 2009, 69
[33] Anti-tumor effects of a selective MET inhibitor on clear cell sarcoma cell lines
Nakai, Takaaki
Imura, Yoshinori
Nakai, Sho
Yasuda, Naohiro
Yamada, Shutaro
Takenaka, Satoshi
Tamiya, Hironari
Tanaka, Takaaki
Araki, Nobuhito
Itoh, Kazuyuki
Yoshikawa, Hideki
Naka, Norifumi
CANCER SCIENCE, 2018, 109 : 569 - 569
[34] PHARMACOLOGICAL PROPERTIES AND ANTI-TUMOR ACTIVITY OF A PREPARATION DIIODO-BENZO-TEPA IN THE EXPERIMENT
TRINUS, FP
SOLOGUB, PY
PROTSENKO, LD
TARNAVSKAYA, MI
NIKOLAEVA, SV
DANILENKO, VS
SHARYKINA, NI
KOLODYAZHNY, VI
ZAIKINA, RG
GONCHARENKO, GV
KOPELNIK, MA
ANDRIANOVA, SM
VOPROSY ONKOLOGII, 1979, 25 (09) : 53 - 58
[35] Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma
Nambotin, Sarah Beseme
Lefrancois, Lydie
Sainsily, Xavier
Berthillon, Pascale
Kim, Miran
Wands, Jack R.
Chevallier, Michele
Jalinot, Pierre
Scoazec, Jean-Yves
Trepo, Christian
Zoulim, Fabien
Merle, Philippe
JOURNAL OF HEPATOLOGY, 2011, 54 (02) : 288 - 299
[36] EGFR tyrosine kinase inhibitor limits tumor relapse through enhancing anti-tumor T cell responses
Liu, Zhida
Han, Chuanhui
Shen, Aijun
Dong, Chunbo
Qiao, Jian
Fu, Yang-Xin
CANCER RESEARCH, 2018, 78 (13)
[37] MLN8054, an Aurora A Kinase inhibitor, demonstrates potent anti-tumor activity in disseminated tumor models
Zhang, M.
Meetze, M.
Huck, J.
Silva, M.
Sells, T.
Claiborne, C.
Manfredi, M.
EJC SUPPLEMENTS, 2006, 4 (12): : 113 - 113
[38] ETS-005, a highly selective TEAD4 palmitoylation inhibitor with potent anti-tumor activity and brain penetrating capability
Lu, Jiajun
Du, Wenpei
Gao, Ming
Fan, Xiaofei
Li, Jinping
Feng, Lijian
Wang, Mengya
Li, Yingjie
Zhong, Xiaofeng
Cui, Wenqi
Zheng, Qiangang
Zhu, Jidong
CANCER RESEARCH, 2024, 84 (06)
[39] BAY 1112054, a highly selective, potent and orally available inhibitor of PTEFb/CDK9, shows convincing anti-tumor activity
Scholz, Arne
Luecking, Ulrich
Siemeister, Gerhard
Lienau, Philip
Eis, Knut
Wengner, Antje
Petersen, Kirstin
Boemer, Ulf
Nussbaumer, Peter
Choidas, Axel
Ruehter, Gerd
Eickhoff, Jan
Schultz-Fademrecht, Carsten
Klebl, Bert
Ince, Stuart
von Nussbaum, Franz
Mumberg, Dominik
Brands, Michael
Ziegelbauer, Karl
CANCER RESEARCH, 2014, 74 (19)
[40] Anti-tumor activity of BMS-595, a novel CK2 kinase inhibitor
Rupnow, Brent A.
Yu, Chiang
Pabalan, Jonathan G.
Roongta, Urvashi V.
Lippy, Jonathan S.
Dongre, Ashok R.
Obermeier, Mary T.
Fura, Aberra
Elzinga, Paul A.
Henley, Benjamin J.
Fargnoli, Joseph
Lee, Francis Y.
Foster, William R.
Tarby, Christine M.
Fink, Brian E.
Tokarski, John S.
Gavai, Ashvinikumar V.
Wong, Tai W.
Hunt, John T.
Vite, Gregory D.
Purandare, Ashok V.
CANCER RESEARCH, 2015, 75

← 1 2 3 4 5 →