High-throughput combinatorial synthesis of substituted benzimidazolones

被引：32
|
作者：
Pan, PC [1 ]
Sun, CM [1 ]
机构：
[1] Natl Dong Hwa Univ, Dept Chem, Shoufeng 974, Hualien, Taiwan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 35期
关键词：
D O I：
10.1016/S0040-4039(99)01276-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient liquid-phase synthesis of substituted benzimidazolones 7 is described. Resin bound o-fluoronitrobenzene 1 is reacted with various primary amines to afford o-nitroaniline derivatives 2. Subsequent reduction of the aromatic nitro group followed by cyclization gives a PEG bound benzimidazole-2-one 4. N-Alkylation of this resin bound scaffold 4 with several electrophiles gives the resulting library in excellent yield and purity after cleavage. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6443 / 6446
页数：4
相关论文
共 50 条
  • [41] CombiGEM — high-throughput identification of combinatorial gene effects
    Liesbet Lieben
    Nature Reviews Genetics, 2015, 16 : 564 - 565
  • [42] The synergy between combinatorial chemistry and high-throughput screening
    Diller, David J.
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2008, 11 (03) : 346 - 355
  • [43] A flexible database for combinatorial and high-throughput materials science
    Frantzen, A
    Sanders, D
    Scheidtmann, J
    Simon, U
    Maier, WF
    QSAR & COMBINATORIAL SCIENCE, 2005, 24 (01): : 22 - 28
  • [44] Combinatorial and high-throughput investigation of growth nanotwin formation
    Alwen, A.
    Liang, A.
    Branicio, P. S.
    Hodge, A. M.
    ACTA MATERIALIA, 2024, 270
  • [45] Combinatorial fabrication and high-throughput characterization of metallic glasses
    Liu Yan-Hui
    ACTA PHYSICA SINICA, 2017, 66 (17)
  • [46] High-Throughput and Combinatorial Approaches for the Development of Multifunctional Polymers
    Baudis, Stefan
    Behl, Marc
    MACROMOLECULAR RAPID COMMUNICATIONS, 2022, 43 (12)
  • [47] Metric Learning for High-Throughput Combinatorial Data Sets
    Vaddi, Kiran
    Wodo, Olga
    ACS COMBINATORIAL SCIENCE, 2019, 21 (11) : 726 - 735
  • [48] High-throughput printing of combinatorial materials from aerosols
    Zeng, Minxiang
    Du, Yipu
    Jiang, Qiang
    Kempf, Nicholas
    Wei, Chen
    Bimrose, Miles V.
    Tanvir, A. N. M.
    Xu, Hengrui
    Chen, Jiahao
    Kirsch, Dylan J.
    Martin, Joshua
    Wyatt, Brian C.
    Hayashi, Tatsunori
    Saeidi-Javash, Mortaza
    Sakaue, Hirotaka
    Anasori, Babak
    Jin, Lihua
    McMurtrey, Michael D.
    Zhang, Yanliang
    NATURE, 2023, 617 (7960) : 292 - +
  • [49] Combinatorial and high-throughput screening approaches for strain engineering
    Liu, Wenshan
    Jiang, Rongrong
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 99 (05) : 2093 - 2104
  • [50] CombiGEM - high-throughput identification of combinatorial gene effects
    Lieben, Liesbet
    NATURE REVIEWS GENETICS, 2015, 16 (10) : 564 - 564
12345