'On-solvent' new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold

被引：21

作者：

Elinson, Michail N. ^{[1
]}

Ryzhkov, Fedor V. ^{[1
]}

Vereshchagin, Anatoly N. ^{[1
]}

Korshunov, Alexander D. ^{[1
]}

Novikov, Roman A. ^{[1
]}

Egorov, Mikhail P. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

MENDELEEV COMMUNICATIONS | 2017年 / 27卷 / 06期

基金：

俄罗斯科学基金会;

关键词：

HYBRID MOLECULAR-SYSTEMS; 2-AMINO-4H-CHROMENE SCAFFOLD; URIDINE; WATER; PASE; POT; CYANOACETATES; NUCLEOTIDES; SUSPENSION; DISCOVERY;

D O I：

10.1016/j.mencom.2017.11.006

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sodium acetate catalyzed assembling of salicylaldehydes, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one in small amount of ethanol gives rapidly (5 min) substituted 4-pyridinyl-2-amino-4H-chromenes in 82-99% yields. This novel domino reaction opens the fast, facile, and flexible way to the new type of functionalized 2-amino-4H-chromene scaffold containing uracil-like moiety, which are relevant compounds for diverse biomedical applications.

引用

页码：559 / 561

页数：3

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