'On-solvent' new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold

被引：21
|
作者：
Elinson, Michail N. [1 ]
Ryzhkov, Fedor V. [1 ]
Vereshchagin, Anatoly N. [1 ]
Korshunov, Alexander D. [1 ]
Novikov, Roman A. [1 ]
Egorov, Mikhail P. [1 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia
来源：
MENDELEEV COMMUNICATIONS | 2017年 / 27卷 / 06期
基金：
俄罗斯科学基金会;
关键词：
HYBRID MOLECULAR-SYSTEMS; 2-AMINO-4H-CHROMENE SCAFFOLD; URIDINE; WATER; PASE; POT; CYANOACETATES; NUCLEOTIDES; SUSPENSION; DISCOVERY;
D O I：
10.1016/j.mencom.2017.11.006
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sodium acetate catalyzed assembling of salicylaldehydes, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one in small amount of ethanol gives rapidly (5 min) substituted 4-pyridinyl-2-amino-4H-chromenes in 82-99% yields. This novel domino reaction opens the fast, facile, and flexible way to the new type of functionalized 2-amino-4H-chromene scaffold containing uracil-like moiety, which are relevant compounds for diverse biomedical applications.
引用
收藏
页码：559 / 561
页数：3
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