The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria

被引：114
|
作者：
Bull, PC
Marsh, K
机构：
[1] KEMRI Ctr Geog Med Res, Coast CGMRC, Kilifi, Kenya
[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DS, England
来源：
TRENDS IN MICROBIOLOGY | 2002年 / 10卷 / 02期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0966-842X(01)02278-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Plasmodium falciparum,the most virulent species of human malaria parasite, causes 1-3 million deaths per year. Because this parasite is susceptible to naturally acquired host immunity the main burden of disease falls on young children. The mechanism of this immunity is still unclear. However, the parasite makes a considerable investment in the insertion of highly polymorphic antigens (parasite-infected-erythrocyte surface antigens, PIESA) on the infected erythrocyte surface, and these antigens are potentially important immune targets.
引用
收藏
页码：55 / 58
页数：4
相关论文
共 50 条
  • [31] Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens
    Ofori, MF
    Dodoo, D
    Staalsoe, T
    Kurtzhals, JAL
    Koram, K
    Theander, TG
    Akanmori, BD
    Hviid, L
    INFECTION AND IMMUNITY, 2002, 70 (06) : 2982 - 2988
  • [32] RELATING ANTIBODIES TO THE SURFACE OF PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTE WITH CLINICAL OUTCOMES
    Attaher, Oumar
    Cisse, Kadidia B.
    Mahamar, Almahamoudou
    Kanoute, Moussa B.
    Diarra, Bakary S.
    Keita, Sekouba
    Dembele, Adama
    Santara, Gaoussou
    Issiaka, Djibrilla
    Traore, Moussa
    Swihart, Bruce
    Duffy, Patrick E.
    Dicko, Alassane
    Fried, Michal
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2015, 93 (04): : 489 - 489
  • [33] The surface of the Plasmodium falciparum-infected erythrocyte
    Smith, JD
    Craig, AG
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2005, 7 : 81 - 93
  • [34] Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens
    Reddy, Sreenivasulu B.
    Anders, Robin F.
    Cross, Nadia
    Mueller, Ivo
    Senn, Nicolas
    Stanisic, Danielle I.
    Siba, Peter M.
    Wahlgren, Mats
    Kironde, Fred
    Beeson, James G.
    Persson, Kristina E. M.
    BMC MICROBIOLOGY, 2015, 15
  • [35] NATURALLY ACQUIRED CIRCUMSPOROZOITE ANTIBODIES AND THEIR ROLE IN PROTECTION IN ENDEMIC FALCIPARUM AND VIVAX MALARIA
    WONGSRICHANALAI, C
    WEBSTER, HK
    PERMPANICH, B
    CHUANAK, N
    KETRANGSRI, S
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 44 (02): : 201 - 204
  • [36] Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens
    Sreenivasulu B. Reddy
    Robin F. Anders
    Nadia Cross
    Ivo Mueller
    Nicolas Senn
    Danielle I. Stanisic
    Peter M. Siba
    Mats Wahlgren
    Fred Kironde
    James G. Beeson
    Kristina E.M. Persson
    BMC Microbiology, 15 (1)
  • [37] Parasitized erythrocyte membrane antigens of Plasmodium brasilianum: Relationships with the ring-infected erythrocyte surface antigen of Plasmodium falciparum
    Sulzer, AJ
    Collins, WE
    Cantella, RA
    Carney, WP
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1995, 53 (06): : 618 - 623
  • [38] Naturally acquired immunity against immature Plasmodium falciparum gametocytes
    Dantzler, Kathleen W.
    Ma, Siyuan
    Ngotho, Priscilla
    Stone, Will J. R.
    Tao, Dingyin
    Rijpma, Sanna
    De Niz, Mariana
    Bark, Sandra K. Nilsson
    Jore, Matthijs M.
    Raaijmakers, Tonke K.
    Early, Angela M.
    Ubaida-Mohien, Ceereena
    Lemgruber, Leandro
    Campo, Joseph J.
    Teng, Andy A.
    Le, Timothy Q.
    Walker, Cassidy L.
    Hermand, Patricia
    Deterre, Philippe
    Davies, D. Huw
    Felgner, Phil
    Morlais, Isabelle
    Wirth, Dyann F.
    Neafsey, Daniel E.
    Dinglasan, Rhoel R.
    Laufer, Miriam
    Huttenhower, Curtis
    Seydel, Karl
    Taylor, Terrie
    Bousema, Teun
    Marti, Matthias
    SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (495)
  • [39] Kinetics of antibody responses to Plasmodium falciparum-infected erythrocyte variant surface antigens
    Kinyanjui, SM
    Bull, P
    Newbold, CI
    Marsh, K
    JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (04): : 667 - 674
  • [40] RELATIONSHIPS BETWEEN CIRCULATING S-ANTIGENS, NATURALLY ACQUIRED ANTIBODIES TO PLASMODIUM-FALCIPARUM EXOANTIGENS AND MALARIA ATTACK IN A MESOENDEMIC AREA
    CHUMPITAZI, BFF
    PEYRON, F
    BOUDIN, C
    PICOT, S
    OURY, B
    AMBROISETHOMAS, P
    ACTA TROPICA, 1992, 50 (04) : 295 - 304
12345