The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria

被引：114

作者：

Bull, PC

Marsh, K

机构：

[1] KEMRI Ctr Geog Med Res, Coast CGMRC, Kilifi, Kenya

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DS, England

来源：

TRENDS IN MICROBIOLOGY | 2002年 / 10卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0966-842X(01)02278-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasmodium falciparum,the most virulent species of human malaria parasite, causes 1-3 million deaths per year. Because this parasite is susceptible to naturally acquired host immunity the main burden of disease falls on young children. The mechanism of this immunity is still unclear. However, the parasite makes a considerable investment in the insertion of highly polymorphic antigens (parasite-infected-erythrocyte surface antigens, PIESA) on the infected erythrocyte surface, and these antigens are potentially important immune targets.

引用

页码：55 / 58

页数：4

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