Design and synthesis of the anticonvulsant Co 2-1068: A novel neuroactive steroid modulator of the GABA(A) receptor

被引：0
|
作者：
Upasani, RB [1 ]
Yang, KC [1 ]
Hawkinson, JE [1 ]
AcostaBurruel, M [1 ]
McLellan, JA [1 ]
Carter, R [1 ]
机构：
[1] COCENSYS INC,IRVINE,CA 92718
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 213卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：174 / MEDI
页数：1
相关论文
共 50 条
  • [31] Design and synthesis of benzimidazole aminoimidazolines as novel alpha(2) adrenergic receptor agonists.
    Jeon, YT
    Lou, C
    Forray, C
    Jorgensen, V
    Nagorny, R
    Branchek, TA
    Gluchowski, C
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 24 - MEDI
  • [32] Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands
    Menegatti, R
    Cunha, AC
    Ferreira, VF
    Perreira, EFR
    El-Nabawi, A
    Eldefrawi, AT
    Albuquerque, EX
    Neves, G
    Rates, SMK
    Fraga, CAM
    Barreiro, EJ
    BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (22) : 4807 - 4813
  • [33] Design, synthesis, docking, and biological evaluation of some novel 5-chloro-2-substituted sulfanylbenzoxazole derivatives as anticonvulsant agents
    Mohamed-Kamal Ibrahim
    Khaled El-Adl
    Mohamed F. Zayed
    Hazem A. Mahdy
    Medicinal Chemistry Research, 2015, 24 : 99 - 114
  • [34] Design, synthesis, docking, and biological evaluation of some novel 5-chloro-2-substituted sulfanylbenzoxazole derivatives as anticonvulsant agents
    Ibrahim, Mohamed-Kamal
    El-Adl, Khaled
    Zayed, Mohamed F.
    Mahdy, Hazem A.
    MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (01) : 99 - 114
  • [35] Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations
    Arefeh Shafie
    Maryam Mohammadi-Khanaposhtani
    Mehdi Asadi
    Nastaran Rahimi
    Parviz Rashidi Ranjbar
    Jahan B. Ghasemi
    Bagher Larijani
    Mohammad Mahdavi
    Hamed Shafaroodi
    Ahmad Reza Dehpour
    Molecular Diversity, 2020, 24 : 179 - 189
  • [36] Design, synthesis and biological evaluation of novel biphenylsulfonamide derivatives as selective AT2 receptor antagonists
    Wang, Danhui
    Zhao, Wenjie
    Zhang, Zuzhi
    Zhang, Yanchun
    Li, Jiaming
    Huang, Weijun
    FRONTIERS IN CHEMISTRY, 2022, 10
  • [37] Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors
    Carotenuto, Alfonso
    Cipolletta, Ersilia
    Gomez-Monterrey, Isabel
    Sala, Marina
    Vernieri, Ermelinda
    Limatola, Antonio
    Bertamino, Alessia
    Musella, Simona
    Sorriento, Daniela
    Grieco, Paolo
    Trimarco, Bruno
    Novellino, Ettore
    Iaccarino, Guido
    Campiglia, Pietro
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 69 : 384 - 392
  • [38] Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations
    Shafie, Arefeh
    Mohammadi-Khanaposhtani, Maryam
    Asadi, Mehdi
    Rahimi, Nastaran
    Ranjbar, Parviz Rashidi
    Ghasemi, Jahan B.
    Larijani, Bagher
    Mahdavi, Mohammad
    Shafaroodi, Hamed
    Dehpour, Ahmad Reza
    MOLECULAR DIVERSITY, 2020, 24 (01) : 179 - 189
  • [39] Quinoxalin-2(1H)-one derived AMPA-receptor antagonists: Design, synthesis, molecular docking and anticonvulsant activity
    El-Helby, Abdel-Ghany A.
    Ayyad, Rezk R. A.
    El-Adl, Khaled
    Elwan, Alaa
    MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (11) : 2967 - 2984
  • [40] Quinoxalin-2(1H)-one derived AMPA-receptor antagonists: Design, synthesis, molecular docking and anticonvulsant activity
    Abdel-Ghany A. El-Helby
    Rezk R. A. Ayyad
    Khaled El-Adl
    Alaa Elwan
    Medicinal Chemistry Research, 2017, 26 : 2967 - 2984
12345