The ins(ide) and outs(ide) of asymmetric stem cell division

被引：38

作者：

Chen, Cuie ^{[1
,2
]}

Fingerhut, Jaclyn M. ^{[1
,3
]}

Yamashita, Yukiko M. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Cellular & Mol Biol Program, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2016年 / 43卷

基金：

美国国家卫生研究院;

关键词：

SPINDLE ORIENTATION; SARA ENDOSOMES; DROSOPHILA NEUROBLASTS; NOTCH TRAFFICKING; CENTROSOME; INHERITANCE; CHECKPOINT; DYNAMICS;

D O I：

10.1016/j.ceb.2016.06.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many adult stem cells divide asymmetrically, generating one stem cell (self-renewal) and one differentiating cell. Balancing self-renewal and differentiation is critical for sustaining tissue homeostasis throughout the life of an organism. Failure to execute asymmetric stem cell division can have profound impacts on tissue homeostasis, resulting in tissue degeneration or hyperplasia/tumorigenic overgrowth. Recent studies have expanded our understanding of both the extracellular and intracellular mechanisms that regulate, reinforce and ensure an asymmetric outcome following stem cell division. In this review, we discuss newly discovered aspects of asymmetric stem cell division that, in concert with well-established mechanisms, contribute to balancing self-renewal and differentiation.

引用

页码：1 / 6

页数：6

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