Cell surface dynamics of CFTR: The ins and outs

被引:27
|
作者
Okiyoneda, Tsukasa [1 ]
Lukacs, Gergely L. [1 ]
机构
[1] Hosp Sick Children, Inst Res, Toronto, ON M5G 1X8, Canada
来源
关键词
endocytosis; recycling; actin; WASP; sorting;
D O I
10.1016/j.bbamcr.2007.01.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ganeshan et al. (Biochem Biophys. Acta 1173 (2007) 192-200) recent study documents the effect of N-WASP inhibition and actin cytoskeleton disruption on the constitutive internalization and recycling of the cystic fibrosis transmembrane conductance regulator (CFTR) channel. The results implicate the cytoskeleton network as a potential modulator of immobilized CFTR pool size at the plasma membrane and the recycling efficiency of endocytosed channel back to the cell surface. Crown Copyright (c) 2007 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:476 / 479
页数:4
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