Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloaddition

被引：16
|
作者：
Elayadi, Hanane [1 ]
Mesnaoui, Mohamed [2 ]
Korba, Brent E. [3 ]
Smietana, Michael [4 ]
Vasseur, Jean Jacques [4 ]
Secrist, John A. [5 ]
Lazrek, Hassan B. [1 ]
机构：
[1] Fac Sci Semlalia, Lab Chim Biomol Subst Nat & React URAC 16, Unite Chim Biomol & Med, Marrakech, Morocco
[2] Fac Sci Semlalia, Lab Mat Condensee & Environm, Marrakech, Morocco
[3] Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Washington, DC 20057 USA
[4] Univ Montpellier 2, Inst Biomol Max Mousseron UMR 5247, CNRS UMI UMII, F-34095 Montpellier 5, France
[5] So Res Inst, Birmingham, AL 35255 USA
来源：
ARKIVOC | 2012年
关键词：
1,2,3-Triazolo ribonucleosides; Na2CuP2O7; click chemistry; CLICK CHEMISTRY; BIOLOGICAL-ACTIVITY; NUCLEOSIDE; POTENT; PHASE;
D O I：
10.3998/ark.5550190.0013.807
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-ribonucleosides by means of 1,3-dipolar cycloaddition between various N-1 propargyl-pyrimidines and 1'-azido2', 3', 5'-tri-O-benzoylribose catalyzed by Na2CuP2O7/sodium ascorbate. All obtained compounds were evaluated for their anti-HCV activity in vitro.
引用
收藏
页码：76 / 89
页数：14
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