Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloaddition

被引：16

作者：

Elayadi, Hanane ^{[1
]}

Mesnaoui, Mohamed ^{[2
]}

Korba, Brent E. ^{[3
]}

Smietana, Michael ^{[4
]}

Vasseur, Jean Jacques ^{[4
]}

Secrist, John A. ^{[5
]}

Lazrek, Hassan B. ^{[1
]}

机构：

[1] Fac Sci Semlalia, Lab Chim Biomol Subst Nat & React URAC 16, Unite Chim Biomol & Med, Marrakech, Morocco

[2] Fac Sci Semlalia, Lab Mat Condensee & Environm, Marrakech, Morocco

[3] Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Washington, DC 20057 USA

[4] Univ Montpellier 2, Inst Biomol Max Mousseron UMR 5247, CNRS UMI UMII, F-34095 Montpellier 5, France

[5] So Res Inst, Birmingham, AL 35255 USA

来源：

ARKIVOC | 2012年

关键词：

1,2,3-Triazolo ribonucleosides; Na2CuP2O7; click chemistry; CLICK CHEMISTRY; BIOLOGICAL-ACTIVITY; NUCLEOSIDE; POTENT; PHASE;

D O I：

10.3998/ark.5550190.0013.807

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-ribonucleosides by means of 1,3-dipolar cycloaddition between various N-1 propargyl-pyrimidines and 1'-azido2', 3', 5'-tri-O-benzoylribose catalyzed by Na2CuP2O7/sodium ascorbate. All obtained compounds were evaluated for their anti-HCV activity in vitro.

引用

页码：76 / 89

页数：14

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