Association and expression analysis of porcine HNF1A gene related to meat and carcass quality traits

被引：8
|
作者：
Kayan, Autchara [1 ,2 ]
Uddin, Muhammad Jasim [1 ,3 ]
Kocamis, Hakan [4 ]
Tesfaye, Dawit [1 ]
Looft, Christian [1 ]
Tholen, Ernst [1 ]
Schellander, Karl [1 ]
Cinar, Mehmet Ulas [1 ]
机构：
[1] Univ Bonn, Inst Anim Sci, Anim Breeding & Husb Grp, D-53115 Bonn, Germany
[2] Kasetsart Univ, Fac Agr, Dapartment Anim Sci, Bangkok 10900, Thailand
[3] Bangladesh Agr Univ, Fac Vet Sci, Dept Med, Mymensingh 2202, Bangladesh
[4] Kirikkale Univ, Fac Vet, Dept Histol & Embryol, TR-71450 Kirikkale, Turkey
来源：
MEAT SCIENCE | 2013年 / 94卷 / 04期
关键词：
HNF1A; Single nucleotide polymorphism; mRNA and protein expression; Methylation; Meat quality; Pig; INTRAMUSCULAR FAT-CONTENT; ACID-COMPOSITION; DNA METHYLATION; QTL; IDENTIFICATION; HEPATOCYTE-NUCLEAR-FACTOR-1-ALPHA; POLYMORPHISMS; ACTIVATION; FATNESS; TARGET;
D O I：
10.1016/j.meatsci.2013.04.015
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The aim of this study was to investigate the association and expression of HNF1A gene as a candidate gene for meat and carcass quality traits in pigs. Statistical analysis revealed that the g.8260 A>G polymorphism significantly associated with pH 24(H), meat percentage and muscle area in the F-2 Duroc x Pietrain (DuPi, n = 313) and with pH 24(L), fat area and backfat thickness in the Pietrain (Pi, n = 110) population. HNF1A mRNA and protein expressions were higher (p < 0.05) in animals with the low post-mortem muscle pH 24(L). The promoter methylation profiling suggested that methylation was not involved on HNF1A expression regulation (p > 0.05) in animal with divergent muscle pH. In conclusion, polymorphism in porcine HNF1A gene could be used as a candidate marker to improve the meat and carcass quality traits, with the consideration of breed-specific effect. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：474 / 479
页数：6
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