Toxoplasma gondii:: generation of the linker domain of dihydrofolate novel truncation mutations in reductase-thymidylate synthase

被引：5
|
作者：
Belperron, AA
Fox, BA
O'Neil, RH
Peaslee, KAW
Horii, T
Anderson, AC
Bzik, DJ [1 ]
机构：
[1] Dartmouth Coll Sch Med, Dept Microbiol & Immunol, Lebanon, NH 03756 USA
[2] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA
[3] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 565, Japan
来源：
EXPERIMENTAL PARASITOLOGY | 2004年 / 106卷 / 3-4期
关键词：
DHFR-TS/m2m3; high-level pyrimethamine resistant dihydrofolate reductase (EC 1.5.1.3)-thymidylate; synthase (EC 2.1.1.45); FLAG; FLAG epitope; pyr(R); high-level pyrimethamine resistance; SERA; serine repeat antigen;
D O I：
10.1016/j.exppara.2004.03.002
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
[No abstract available]
引用
收藏
页码：179 / 182
页数：4
相关论文
共 50 条
  • [31] Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene
    Tirakarn, Srisuda
    Riangrungroj, Pinpunya
    Kongsaeree, Palangpon
    Imwong, Mallika
    Yuthavong, Yongyuth
    Leartsakulpanich, Ubolsree
    PARASITOLOGY INTERNATIONAL, 2012, 61 (02) : 324 - 332
  • [32] Physical mapping across the dihydrofolate reductase-thymidylate synthase chromosome of Leishmania major
    Tosi, LRO
    Casagrande, L
    Beverley, SM
    Cruz, AK
    PARASITOLOGY, 1997, 114 : 521 - 529
  • [33] Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase
    Natpasit Chaianantakul
    Rachada Sirawaraporn
    Worachart Sirawaraporn
    Malaria Journal, 12
  • [34] PRODUCTION OF HETERO-DIMERIC DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE BIFUNCTIONAL ENZYME
    IWAKURA, M
    KOKUBU, T
    JOURNAL OF BIOCHEMISTRY, 1995, 118 (01): : 67 - 74
  • [35] DEFINING THE ROLE OF MUTATIONS IN PLASMODIUM VIVAX DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE USING A PLASMODIUM FALCIPARUM EXPRESSION SYSTEM
    Auliff, Alyson M.
    Adams, John H.
    O'Neii, Michael T.
    Cheng, Qin
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2010, 83 (05): : 143 - 143
  • [36] Biochemical evidence for the presence of a bifunctional dihydrofolate reductase-thymidylate synthase in plant species
    Balestrazzi, A
    Branzoni, M
    Carbonera, D
    Parisi, B
    Cella, R
    JOURNAL OF PLANT PHYSIOLOGY, 1995, 147 (02) : 263 - 266
  • [37] Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity
    Wattanarangsan, J
    Chusacultanachai, S
    Yuvaniyama, J
    Kamchonwongpaisan, S
    Yuthavong, Y
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2003, 126 (01) : 97 - 102
  • [38] Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase
    Mudeppa, Devaraja G.
    Pang, Cullen K. T.
    Tsuboi, Takafumi
    Endo, Yaeta
    Buckner, Fredrick S.
    Varani, Gabriele
    Rathod, Pradipsinh K.
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2007, 151 (02) : 216 - 219
  • [39] Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
    Begley, Darren W.
    Edwards, Thomas E.
    Raymond, Amy C.
    Smith, Eric R.
    Hartley, Robert C.
    Abendroth, Jan
    Sankaran, Banumathi
    Lorimer, Donald D.
    Myler, Peter J.
    Staker, Bart L.
    Stewart, Lance J.
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 67 : 1070 - 1077
  • [40] POINT MUTATIONS IN THE DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE GENE AS THE MOLECULAR-BASIS FOR PYRIMETHAMINE RESISTANCE IN PLASMODIUM-FALCIPARUM
    ZOLG, JW
    PLITT, JR
    CHEN, GX
    PALMER, S
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 36 (03) : 253 - 262
12345