Toxoplasma gondii:: generation of the linker domain of dihydrofolate novel truncation mutations in reductase-thymidylate synthase

被引：5
|
作者：
Belperron, AA
Fox, BA
O'Neil, RH
Peaslee, KAW
Horii, T
Anderson, AC
Bzik, DJ [1 ]
机构：
[1] Dartmouth Coll Sch Med, Dept Microbiol & Immunol, Lebanon, NH 03756 USA
[2] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA
[3] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 565, Japan
来源：
EXPERIMENTAL PARASITOLOGY | 2004年 / 106卷 / 3-4期
关键词：
DHFR-TS/m2m3; high-level pyrimethamine resistant dihydrofolate reductase (EC 1.5.1.3)-thymidylate; synthase (EC 2.1.1.45); FLAG; FLAG epitope; pyr(R); high-level pyrimethamine resistance; SERA; serine repeat antigen;
D O I：
10.1016/j.exppara.2004.03.002
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
[No abstract available]
引用
收藏
页码：179 / 182
页数：4
相关论文
共 50 条
  • [11] In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase
    Reynolds, MG
    Oh, J
    Roos, DS
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (04) : 1271 - 1277
  • [12] STABLE MOLECULAR-TRANSFORMATION OF TOXOPLASMA-GONDII - A SELECTABLE DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE MARKER BASED ON DRUG-RESISTANCE MUTATIONS IN MALARIA
    DONALD, RGK
    ROOS, DS
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11703 - 11707
  • [13] A transgenic Neospora caninum strain based on mutations of the dihydrofolate reductase-thymidylate synthase gene
    Pereira, Luiz Miguel
    Baroni, Luciana
    Yatsuda, Ana Patricia
    EXPERIMENTAL PARASITOLOGY, 2014, 138 : 40 - 47
  • [14] Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase
    Chanama, M
    Chitnumsub, P
    Yuthavong, Y
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2005, 139 (01) : 83 - 90
  • [15] Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase
    Elcock, AH
    Potter, MJ
    Matthews, DA
    Knighton, DR
    McCammon, JA
    JOURNAL OF MOLECULAR BIOLOGY, 1996, 262 (03) : 370 - 374
  • [16] Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase
    Vanichtanankul, Jarunee
    Yoomuang, Aphisit
    Taweechai, Supannee
    Saeyang, Thanaya
    Pengon, Jutharat
    Yuvaniyama, Jirundon
    Tarnchompoo, Bongkoch
    Yuthavong, Yongyuth
    Kamchonwongpaisan, Sumalee
    ACS CHEMICAL BIOLOGY, 2022, : 1691 - 1702
  • [17] Construction of a homodimeric dihydrofolate reductase-thymidylate synthase bifunctional enzyme
    Trujillo, M
    Duncan, R
    Santi, DV
    PROTEIN ENGINEERING, 1997, 10 (05): : 567 - 573
  • [18] STUDY OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE IN PLASMODIUM-FALCIPARUM
    INSELBURG, J
    ZHANG, RD
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1988, 39 (04): : 328 - 336
  • [19] STRUCTURE OF AND KINETIC CHANNELING IN BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
    KNIGHTON, DR
    KAN, CC
    HOWLAND, E
    JANSON, CA
    HOSTOMSKA, Z
    WELSCH, KM
    MATTHEWS, DA
    NATURE STRUCTURAL BIOLOGY, 1994, 1 (03): : 186 - 194
  • [20] FUNCTIONAL CHARACTERIZATION OF PLASMODIUM OVALE DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
    Tirakarn, Srisuda
    Leartsakulpanich, Ubolsree
    Kongsaeree, Palangpon
    Yuthawong, Yongyuth
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2009, 81 (05): : 60 - 61
12345