Regioselective synthesis and antibacterial evaluation of a new class of substituted pyrazolo[3,4-b]pyridines

被引：9

作者：

Mamaghani, Manouchehr ^{[1
]}

Tabatabaeian, Khalil ^{[1
]}

Bayat, Mitra ^{[1
]}

Nia, Roghayeh Hossein ^{[1
]}

Rassa, Mehdi ^{[2
]}

机构：

[1] Univ Guilan, Dept Chem, Fac Sci, Rasht, Iran

[2] Univ Guilan, Dept Biol, Fac Sci, Rasht, Iran

来源：

JOURNAL OF CHEMICAL RESEARCH | 2013年 / 08期

关键词：

pyrazolo[3,4-b]pyridine; pyrazole; indole; Fe3+-montmorillonite; ultrasound; antibacterial activity; DERIVATIVES;

D O I：

10.3184/174751913X13735444714766

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New derivatives of polyfunctional pyrazolo[3,4-b] pyridines were synthesised via a regioselective one-pot three-component reaction of 3-(cyanoacetyl) indole, 5-amino-3-methylpyrazole and arylaldehydes in excellent yields using Fe3+-montmorillonite as a reusable catalyst under conventional conditions and ultrasonic irradiation. In particular, valuable features of this method include high reaction rate, employment of a reusable catalyst, straightforward procedure, the easy work-up of the products and mild reaction conditions. The antibacterial activities of the synthesised products were examined which showed promising activities.

引用

页码：494 / 498

页数：5

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