Impairment of olfaction is a characteristic and early feature of Parkinson's disease. Recent data indicate that >95% of patients with Parkinson's disease present with significant olfactory loss. Deficits in the sense of smell may precede clinical motor symptoms by years and can be used to assess the risk for developing Parkinson's disease in otherwise asymptomatic individuals. This paper summarizes the available information about olfactory function in Parkinson's disease, indicating the advantageous use of olfactory probes in early and differential diagnosis.
机构:Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA 19104 USA
Morley, James F.
Duda, John E.
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Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA 19104 USAPhiladelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA 19104 USA
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Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Brain Res Inst, Seoul 120752, South Korea
Yonsei Univ, Dept Neurol, Wonju Coll Med, Wonju, South KoreaYonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Hong, Jin Yong
Sunwoo, Mun Kyung
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Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Brain Res Inst, Seoul 120752, South Korea
Bundang Jesaeng Gen Hosp, Dept Neurol, Seongnam, South KoreaYonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Sunwoo, Mun Kyung
Ham, Jee Hyun
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Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Brain Res Inst, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Ham, Jee Hyun
Lee, Jae Jung
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Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Brain Res Inst, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Lee, Jae Jung
Lee, Phil Hyu
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Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Brain Res Inst, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South KoreaYonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Lee, Phil Hyu
Sohn, Young H.
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Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Brain Res Inst, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea