Nanofabricated upconversion nanoparticles for photodynamic therapy

被引：115

作者：

Ungun, Baris ^{[1
]}

Prud'homme, Robert K. ^{[2
]}

Budijono, Stephanie J. ^{[1
]}

Shan, Jingning ^{[2
]}

Lim, Shuang Fang ^{[2
,3
]}

Ju, Yiguang ^{[2
]}

Austin, Robert ^{[3
]}

机构：

[1] Princeton Univ, Dept Chem Engn, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Mech & Aerosp Engn, Princeton, NJ 08544 USA

[3] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 01期

基金：

美国国家科学基金会;

关键词：

ORGANIC ACTIVES; SINGLET OXYGEN; ACID;

D O I：

10.1364/OE.17.000080

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques. (C) 2008 Optical Society of America

引用

页码：80 / 86

页数：7

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