Cardiac mechanosensitivity and stretch-activated ion channels

被引：21
|
作者：
Bett, GCL
Sachs, F
机构：
[1] Department of Biophysical Sciences, State University of New York, Buffalo
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1997年 / 7卷 / 01期
关键词：
D O I：
10.1016/S1050-1738(96)00119-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs. (C) 1997, Elsevier Science Inc.
引用
收藏
页码：4 / 8
页数：5
相关论文
共 50 条
  • [11] STRETCH-ACTIVATED ION CHANNELS IN NEONATAL VENTRICULAR MYOCYTES
    CHEN, VK
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1990, 588 : 349 - 350
  • [12] Stretch-activated ion channels in human leukemia cells
    A. V. Staruschenko
    Y. A. Negulyaev
    E. A. Vedernikova
    Neurophysiology, 2000, 32 : 134 - 135
  • [13] Stretch-activated channels: a mini-review. Are stretch-activated channels an ocular barometer?
    Kalapesi, FB
    Tan, JCH
    Coroneo, MT
    CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2005, 33 (02): : 210 - 217
  • [14] Role of stretch-activated ion channels in cell migration
    Munevar, S
    Dembo, M
    Wang, YL
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 42A - 42A
  • [15] Stretch-activated ion channels in human leukemia cells
    Staruschenko, AV
    Negulyaev, YA
    Vedernikova, EA
    NEUROPHYSIOLOGY, 2000, 32 (03) : 134 - 135
  • [16] CHARACTERIZATION OF STRETCH-ACTIVATED ION CHANNELS IN XENOPUS OOCYTES
    YANG, XC
    SACHS, F
    JOURNAL OF PHYSIOLOGY-LONDON, 1990, 431 : 103 - 122
  • [17] Cardiac contractility increased by stretch-activated ion channels following a change in perfusion pressure
    Lamberts, RR
    Van Rijen, MH
    Sipkema, P
    Fransen, P
    Sys, S
    Westerhof, N
    CIRCULATION, 2000, 102 (18) : 216 - 216
  • [18] MECHANOSENSITIVITY OF THE HUMAN DETRUSOR IN RESPONSE TO STRETCH IS REGULATED BY STRETCH-ACTIVATED TWO-PORE DOMAIN POTASSIUM CHANNELS
    Lei, Qi
    Pan, Xiao-Qing
    Malkowicz, Stanley
    Guzzo, Thomas
    Malykhina, Anna
    JOURNAL OF UROLOGY, 2013, 189 (04): : E112 - E113
  • [19] STRETCH-ACTIVATED ION CHANNELS IN GROWTH CONES OF SNAIL NEURONS
    SIGURDSON, WJ
    MORRIS, CE
    JOURNAL OF NEUROSCIENCE, 1989, 9 (08): : 2801 - 2808
  • [20] STRETCH-ACTIVATED COMPOSITE ION CHANNELS IN BACILLUS-SUBTILIS
    ZORATTI, M
    PETRONILLI, V
    SZABO, I
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 168 (02) : 443 - 450
12345