Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

被引：4

作者：

Ablise, M. ^{[1
,3
]}

Cartier, A. ^{[2
]}

Siest, G. ^{[3
]}

Visvikis, S. ^{[3
]}

Loppinet, V. ^{[3
]}

机构：

[1] Xinjiang Med Univ, Coll Pharm, Urumqi 830054, Peoples R China

[2] Univ Henri Poincare, Fac Sci, UMR 7565, F-54000 Nancy, France

[3] Univ Henri Poincare, Fac Pharm, INSERM 525, F-54000 Nancy, France

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 02期

关键词：

molecular modeling; hypolipidemic pharmacophore; EMO and GEOMOS programs; semi-empirical PM3 method; glycyrrhetinic acid derivatives;

D O I：

10.2174/1389557024605528

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.

引用

页码：97 / 102

页数：6

共 50 条

[41] Lipid parameters, lipid lowering drugs and the risk of venous thromboembolism
Delluc, Aurelien
Malecot, Jean-Marc
Kerspern, Helene
Nowak, Emmanuel
Carre, Jean-Luc
Mottier, Dominique
Le Gal, Gregoire
Lacut, Karine
ATHEROSCLEROSIS, 2012, 220 (01) : 184 - 188
[42] Lipid-lowering drugs, lipid parameters and venous thromboembolism
Lacut, K.
Malecot, J.
Delluc, A.
Couturaud, F.
Kerspern, H.
Carre, J.
Mottier, D.
Oger, E.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 1030 - 1031
[43] New lipid lowering drugs and new effects of old drugs
Dujovne, CA
CURRENT OPINION IN LIPIDOLOGY, 1997, 8 (06) : 362 - 368
[44] Lipid-Lowering Drugs and Circulating Adiponectin
Wanders, Desiree
Plaisance, Eric P.
Judd, Robert L.
ADIPONECTIN, 2012, 90 : 341 - 374
[45] PLASMA CARNITINE AND LIPID-LOWERING DRUGS
NESTRUCK, AC
PANDE, SV
DAVIGNON, J
ATHEROSCLEROSIS, 1985, 55 (03) : 353 - 356
[46] TIMING OF INTAKE OF LIPID LOWERING DRUGS - IS THAT OF IMPORTANCE
HANEFELD, M
KLINISCHE WOCHENSCHRIFT, 1989, 67 (09): : 511 - 512
[47] Lipid-lowering drugs in the management of hyperlipidaemia
Bhatnagar, D
PHARMACOLOGY & THERAPEUTICS, 1998, 79 (03) : 205 - 230
[48] LIPID-LOWERING DRUGS .1.
GRATSIANSKY, NA
KARDIOLOGIYA, 1994, 34 (3-4) : 49 - 61
[49] LIPID LOWERING DRUGS - MECHANISMS AND ACTIONS - PREFACE
STANGE, EF
DITSCHUNEIT, HH
VONBERGMANN, K
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1991, 40 : S1 - S1
[50] Lipid-lowering drugs and risk for cancer
Pedersen, Terje R.
CURRENT ATHEROSCLEROSIS REPORTS, 2009, 11 (05) : 350 - 357

← 1 2 3 4 5 →