Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

被引：4
|
作者：
Ablise, M. [1 ,3 ]
Cartier, A. [2 ]
Siest, G. [3 ]
Visvikis, S. [3 ]
Loppinet, V. [3 ]
机构：
[1] Xinjiang Med Univ, Coll Pharm, Urumqi 830054, Peoples R China
[2] Univ Henri Poincare, Fac Sci, UMR 7565, F-54000 Nancy, France
[3] Univ Henri Poincare, Fac Pharm, INSERM 525, F-54000 Nancy, France
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 02期
关键词：
molecular modeling; hypolipidemic pharmacophore; EMO and GEOMOS programs; semi-empirical PM3 method; glycyrrhetinic acid derivatives;
D O I：
10.2174/1389557024605528
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.
引用
收藏
页码：97 / 102
页数：6
相关论文
共 50 条
  • [11] LIPID-LOWERING DRUGS
    MCLOUGHLIN, I
    CLARKE, P
    BRITISH JOURNAL OF PSYCHIATRY, 1989, 154 : 275 - 276
  • [12] Lipid-lowering drugs
    Pahan, K.
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (10) : 1165 - 1178
  • [13] Lipid-lowering drugs
    Andréjak, M
    Caron, J
    Libersa, C
    Thery, C
    THERAPIE, 2003, 58 (01): : 1 - 2
  • [14] Lipid-Lowering Drugs
    不详
    MEDICAL LETTER ON DRUGS AND THERAPEUTICS, 2016, 58 (1506): : 133 - 140
  • [15] Forum lipid lowering drugs
    Ritter, MM
    PERFUSION, 1997, 10 (09): : 324 - 324
  • [16] LIPID-LOWERING DRUGS
    不详
    MEDICAL LETTER ON DRUGS AND THERAPEUTICS, 1985, 27 (695): : 74 - 76
  • [17] Lipid lowering drugs in diabetes - Lipid lowering has opthalamic benefits
    Sheth, HG
    Aslam, S
    Davies, N
    BRITISH MEDICAL JOURNAL, 2006, 332 (7552): : 1272 - 1273
  • [18] IDENTIFICATION AND DETERMINATION OF CHOLESTEROL-LOWERING DRUGS BY DENSITOMETRIC METHOD
    Wyszomirska, Elzbieta
    Czerwinska, Krystyna Magdalena
    Kublin, Elzbieta Slawomira
    ACTA POLONIAE PHARMACEUTICA, 2020, 77 (05): : 685 - 697
  • [19] Lipid-lowering drugs and homocysteine - A comparison between statins and other lipid-lowering drugs
    Jankowski, P
    Kawecka-Jaszcz, K
    ATHEROSCLEROSIS, 2004, 172 (01) : 191 - 194
  • [20] Molecular similarity for pharmacophore mapping.
    Perkins, TDJ
    Mills, JEJ
    Dean, PM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 337 - COMP
12345