Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

被引：4
|
作者：
Ablise, M. [1 ,3 ]
Cartier, A. [2 ]
Siest, G. [3 ]
Visvikis, S. [3 ]
Loppinet, V. [3 ]
机构：
[1] Xinjiang Med Univ, Coll Pharm, Urumqi 830054, Peoples R China
[2] Univ Henri Poincare, Fac Sci, UMR 7565, F-54000 Nancy, France
[3] Univ Henri Poincare, Fac Pharm, INSERM 525, F-54000 Nancy, France
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 02期
关键词：
molecular modeling; hypolipidemic pharmacophore; EMO and GEOMOS programs; semi-empirical PM3 method; glycyrrhetinic acid derivatives;
D O I：
10.2174/1389557024605528
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.
引用
收藏
页码：97 / 102
页数：6
相关论文
共 50 条
  • [1] Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2
    Zhu, Shengnan
    Yuan, Qingning
    Li, Xinzhu
    He, Xinheng
    Shen, Shiyi
    Wang, Dongxue
    Li, Junrui
    Cheng, Xi
    Duan, Xiaoqun
    Xu, H. Eric
    Duan, Jia
    CELL REPORTS, 2023, 42 (11):
  • [2] LIPID LOWERING DRUGS
    GALTON, DJ
    COLLINS, R
    TOBERT, J
    JACKSON, RL
    NEWTON, RS
    GHISELLI, G
    SANDERS, T
    SHEPHERD, J
    JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1990, 83 (11) : 750 - 752
  • [3] LIPID LOWERING DRUGS
    BOCANEGRA, TS
    TOBERT, JA
    BRITISH MEDICAL JOURNAL, 1990, 300 (6733): : 1195 - 1195
  • [4] NEW DRUGS - LIPID LOWERING DRUGS
    OCONNOR, P
    FEELY, J
    SHEPHERD, J
    BMJ-BRITISH MEDICAL JOURNAL, 1990, 300 (6725): : 667 - 672
  • [5] Lipid-lowering drugs
    K. Pahan
    Cellular and Molecular Life Sciences CMLS, 2006, 63 : 1165 - 1178
  • [6] LIPID-LOWERING DRUGS
    不详
    MEDICAL LETTER ON DRUGS AND THERAPEUTICS, 1980, 22 (16): : 65 - 66
  • [7] Lipid-Lowering Drugs
    不详
    MEDICAL LETTER ON DRUGS AND THERAPEUTICS, 2022, 64 (1659): : 145 - +
  • [8] LIPID-LOWERING DRUGS
    THOMPSON, GR
    LANCET, 1988, 1 (8585): : 597 - 597
  • [9] Lipid-Lowering Drugs
    不详
    MEDICAL LETTER ON DRUGS AND THERAPEUTICS, 2019, 61 (1565): : 17 - 24
  • [10] LIPID LOWERING DRUGS AND HYPERLIPIDEMIA
    LEVY, RI
    RIFKIND, BM
    DRUGS, 1973, 6 (01) : 12 - 45
12345