Synthesis of artemisinin derived glycoconjugates inspired by click chemistry

被引：9
|
作者：
Goswami, Lakshmi [1 ,2 ]
Paul, Sayantan [1 ,2 ]
Kotammagari, Tharun K. [1 ,2 ]
Bhattacharya, Asish K. [1 ,2 ]
机构：
[1] CSIR Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
[2] Acad Sci & Innovat Res AcSIR, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
来源：
NEW JOURNAL OF CHEMISTRY | 2019年 / 43卷 / 10期
关键词：
AZIDE-ALKYNE CYCLOADDITION; ANTIMALARIAL-DRUG; DERIVATIVES; ENDOPEROXIDES; NITRILES; ETHER; PHASE;
D O I：
10.1039/c8nj05737k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein we describe the synthesis of artemisinin based glycoconjugates (9a-i) through employing a Cu(i)-catalysed reaction between -propargylated dihydroartemisinin (7a) and azido sugars (8a-i), with moderate to excellent yields. Our synthesized artemisinin based glycoconjugates (9a-i) could prove to be an interesting class of bioactive molecules, suitable for the study of their various biological activities.
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页码：4017 / 4021
页数：5
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