Synthesis of artemisinin derived glycoconjugates inspired by click chemistry

被引：9
|
作者：
Goswami, Lakshmi [1 ,2 ]
Paul, Sayantan [1 ,2 ]
Kotammagari, Tharun K. [1 ,2 ]
Bhattacharya, Asish K. [1 ,2 ]
机构：
[1] CSIR Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
[2] Acad Sci & Innovat Res AcSIR, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
来源：
NEW JOURNAL OF CHEMISTRY | 2019年 / 43卷 / 10期
关键词：
AZIDE-ALKYNE CYCLOADDITION; ANTIMALARIAL-DRUG; DERIVATIVES; ENDOPEROXIDES; NITRILES; ETHER; PHASE;
D O I：
10.1039/c8nj05737k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein we describe the synthesis of artemisinin based glycoconjugates (9a-i) through employing a Cu(i)-catalysed reaction between -propargylated dihydroartemisinin (7a) and azido sugars (8a-i), with moderate to excellent yields. Our synthesized artemisinin based glycoconjugates (9a-i) could prove to be an interesting class of bioactive molecules, suitable for the study of their various biological activities.
引用
下载
收藏
页码：4017 / 4021
页数：5
相关论文
共 50 条
  • [31] Synthesis of Glycopeptides by Click Chemistry
    Tomabechi, Yusuke
    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 2015, 27 (154) : 63 - 65
  • [32] Click chemistry inspired facile synthesis and bioevaluation of novel triazolyl analogs of D-(+)-pinitol
    Shakeel-u-Rehman
    Bhat, Khursheed A.
    Lone, Shabir H.
    Malik, Fayaz A.
    ARABIAN JOURNAL OF CHEMISTRY, 2019, 12 (08) : 3479 - 3489
  • [33] Click chemistry mediated synthesis of bio-inspired phosphonyl-functionalized ionic liquids
    Braun, Richard A.
    Bradfield, Joseph L.
    Henderson, Codey B.
    Mobarrez, Niloufar
    Sheng, Yinghong
    O'Brien, Richard A.
    Stenson, Alexandra C.
    Davis, James H., Jr.
    Mirjafari, Arsalan
    GREEN CHEMISTRY, 2015, 17 (02) : 1259 - 1268
  • [34] Click chemistry inspired synthesis and bioevaluation of novel triazolyl derivatives of osthol as potent cytotoxic agents
    Farooq, Saleem
    Shakeel-u-Rehman
    Hussain, Aashiq
    Hamid, Abid
    Qurishi, Mushtaq A.
    Koul, Surrinder
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 84 : 545 - 554
  • [35] Click chemistry inspired synthesis of andrographolide triazolyl conjugates for effective fluorescent sensing of ferric ions
    Pandey, Nishant
    Jyoti
    Singh, Mangat
    Dwivedi, Pratibha
    Sahoo, Subash C.
    Mishra, Bhuwan B.
    NATURAL PRODUCT RESEARCH, 2022, 36 (21) : 5438 - 5448
  • [36] Click Chemistry - Inspired Synthesis of Porphyrin Hybrid Glycodendrimers as Fluorescent Sensor for Cu(II) Ions
    Agrahari, Anand K.
    Kumar, Sunil
    Pandey, Mrituanjay D.
    Rajkhowa, Sanchayita
    Jaiswal, Manoj K.
    Tiwari, Vinod K.
    CHEMISTRYSELECT, 2022, 7 (28):
  • [37] 10 Years of Click Chemistry: Synthesis and Applications of Ferrocene-Derived Triazoles
    Ganesh, Venkataraman
    Sudhir, V. Sai
    Kundu, Taraknath
    Chandrasekaran, Srinivasan
    CHEMISTRY-AN ASIAN JOURNAL, 2011, 6 (10) : 2670 - 2694
  • [38] Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry
    Howell, Lesley A.
    Howman, Aaron
    O'Connell, Maria A.
    Mueller, Anja
    Searcey, Mark
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (20) : 5880 - 5883
  • [39] Click chemistry for the synthesis of biobased polymers and networks derived from vegetable oils
    Tremblay-Parrado, Khantutta-Kim
    Garcia-Astrain, Clara
    Averous, Luc
    GREEN CHEMISTRY, 2021, 23 (12) : 4296 - 4327
  • [40] A double-click approach to the protecting group free synthesis of glycoconjugates
    Alexander, S. R.
    Williams, G. M.
    Brimble, M. A.
    Fairbanks, A. J.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 16 (08) : 1258 - 1262
12345