Trabectedin A drug from the sea that strikes tumor-associated macrophages

被引：50

作者：

Allavena, Paola ^{[1
]}

Germano, Giovanni ^{[1
]}

Belgiovine, Cristina ^{[1
]}

D'Incalci, Maurizio ^{[2
]}

Mantovani, Alberto ^{[1
,3
]}

机构：

[1] Clin & Res Inst Humanitas, Milan, Italy

[2] Mario Negri Inst Pharmacol Res, Milan, Italy

[3] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 06期

关键词：

tumor-associated macrophages; chemotherapy; micro-environment; angiogenesis; marine drug; ANTITUMOR-ACTIVITY;

D O I：

10.4161/onci.24614

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-associated macrophages (TAMs) and other myeloid cells that infiltrate neoplastic lesions promote tumor progression and are associated with poor patient prognosis. We have recently demonstrated that trabectedin, a licensed and commercially available anticancer agent, is selectively cytotoxic for TAMs and their circulating precursors (monocytes). The macrophage-depleting effect of trabectedin is a key component of its antitumor activity.

引用

页数：3

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