Trabectedin A drug from the sea that strikes tumor-associated macrophages

被引：50
|
作者：
Allavena, Paola [1 ]
Germano, Giovanni [1 ]
Belgiovine, Cristina [1 ]
D'Incalci, Maurizio [2 ]
Mantovani, Alberto [1 ,3 ]
机构：
[1] Clin & Res Inst Humanitas, Milan, Italy
[2] Mario Negri Inst Pharmacol Res, Milan, Italy
[3] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 06期
关键词：
tumor-associated macrophages; chemotherapy; micro-environment; angiogenesis; marine drug; ANTITUMOR-ACTIVITY;
D O I：
10.4161/onci.24614
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor-associated macrophages (TAMs) and other myeloid cells that infiltrate neoplastic lesions promote tumor progression and are associated with poor patient prognosis. We have recently demonstrated that trabectedin, a licensed and commercially available anticancer agent, is selectively cytotoxic for TAMs and their circulating precursors (monocytes). The macrophage-depleting effect of trabectedin is a key component of its antitumor activity.
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页数：3
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