Tumor-associated macrophages in cancers

被引：96
|
作者：
Hu, W. [1 ,2 ,3 ]
Li, X. [1 ,2 ,3 ]
Zhang, C. [1 ]
Yang, Y. [1 ]
Jiang, J. [2 ,3 ]
Wu, C. [1 ,2 ,3 ]
机构：
[1] Soochow Univ, Dept Oncol, Affiliated Hosp 3, 185 Juqian St, Changzhou, Peoples R China
[2] Soochow Univ, Dept Tumor Biol Treatment, Affiliated Hosp 3, 185 Juqian St, Changzhou, Peoples R China
[3] Jiangsu Engn Res Ctr Tumor Immunotherapy, Changzhou, Peoples R China
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2016年 / 18卷 / 03期
关键词：
Tumor-associated macrophages; Cancer; HELICOBACTER-PYLORI INFECTION; SUPPRESSES LIVER METASTASIS; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; EXPRESSING CD204; M2; MACROPHAGES; CELLS; POLARIZATION; SURVIVAL; INVASION;
D O I：
10.1007/s12094-015-1373-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor-associated macrophages (TAMs) are major component of leukocytic infiltrate of tumors and play important roles in progression and regression of tumors. Tumor microenvironment determines the mutual conversion between M1 and M2 macrophages. In many kinds of tumors, M2 type macrophages are of the majority in TAMs and promote tumor progression and metastasis. The dynamic balance and interaction between TAMs and tumor cells have important effects on the occurrence and development of tumor. TAMs in malignant tumors are useful for clinical diagnosis and may provide a novel target for cancer treatment.
引用
收藏
页码：251 / 258
页数：8
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