Design and discovery of macrocyclic diaminopropanes as potent inhibitors of BACE1

被引：0

作者：

Marcin, Lawrence R. ^{[1
]}

Thompson, Lorin A. ^{[1
]}

Higgins, Mendi A. ^{[1
]}

Shi, JianLiang ^{[1
]}

Boy, Kenneth M. ^{[1
]}

Olson, Richard E. ^{[1
]}

Good, Andrew C. ^{[2
]}

Burton, Catherine R. ^{[3
]}

Barten, Donna M. ^{[4
]}

Muckelbauer, Jodi K. ^{[5
]}

Calambur, Deepa ^{[5
]}

Camac, Daniel M. ^{[5
]}

Chang, ChiehYing ^{[5
]}

Toyn, Jeremy H. ^{[3
]}

Lentz, Kimberley A. ^{[6
]}

Grace, James E. ^{[6
]}

Herbst, Grace John J. ^{[7
]}

Marino, Anthony M. ^{[6
]}

Meredith, Jere E. ^{[3
]}

Albright, Charlie F. ^{[3
]}

Macor, John E. ^{[8
]}

机构：

[1] Bristol Myers Squibb Res & Dev, Neurosci Discovery Chem, Wallingford, CT 06492 USA

[2] Genzyme Corp, Cambridge, MA USA

[3] Bristol Myers Squibb Co, Neurosci Biol, New York, NY 10154 USA

[4] Bristol Myers Squibb Co, Neurosci Discovery Biol, New York, NY 10154 USA

[5] Bristol Myers Squibb Co, Macromol Crystallog, New York, NY 10154 USA

[6] Bristol Myers Squibb Co, Pharmaceut Candidate Optimizat, New York, NY 10154 USA

[7] Bristol Myers Squibb Co, Lead Profiling, New York, NY 10154 USA

[8] Bristol Myers Squibb Res & Dev, Neurosci Chem, Wallingford, CT 06492 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 238卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

212-MEDI

引用

页数：1

共 50 条

[31] Macrocyclic phosphino dipeptide isostere inhibitors of β-secretase (BACE1) with improved serum stability
Manzenrieder, Florian
Huber, Timo
Kuttruff, Christian A.
Dorner-Ciossek, Cornelia
Kessler, Horst
JOURNAL OF PEPTIDE SCIENCE, 2008, 14 (08) : 121 - 121
[32] MEDI 296-Pyrrolidines as conformationally constrained diaminopropanes: A versatile scaffold for potent inhibitors of BACE-1
Guernon, Jason M.
Thompson, Lorin A., III
Macor, John E.
Tebben, Andrew J.
Good, Andrew
Burton, Catherine R.
Barten, Donna M.
Marcinkeviciene, Jovita
Toyn, Jeremy H.
Albright, Charlie
Muckelbauer, Jodi K.
Camac, Daniel
Zvyaga, Tatyana
Grace, James
Lentz, Kimberly
Boy, Kenneth M.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
[33] Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1
Kortum, Steven W.
Benson, Timothy E.
Bienkowski, Michael J.
Emmons, Thomas L.
Prince, D. Bryan
Paddock, Donna J.
Tomasselli, Alfredo G.
Moon, Joseph B.
LaBorde, Alice
TenBrink, Ruth E.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (12) : 3378 - 3383
[34] Modeling Potenial BACE1 Inhibitors
Guevara, Johnny
Mai Zahran
Department, Alberto
FASEB JOURNAL, 2018, 32 (01):
[35] New aminohydantoins as BACE1 inhibitors
Malamas, Michael S.
Robichaud, Albert
Erdei, Jim
Quagliato, Dominick
Fobare, William
Porte, Alex
Kim, Jean
Solvibile, William
Zhou, Ping
McDevitt, Robert
Morris, Koi
Antane, Schuyler
Turner, Jim
Wagner, Erik
Fan, Kristi
Bard, Jonathan
Jacobsen, Steve
Reinhart, Peter
Pangalos, Menelas
Riddell, David
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
[36] Discovery of a novel sulfone series of BACE1 inhibitors for Alzheimer's disease
Wu, Wen-Lian
Bennett, Chad
Burnett, Duane
Chen, Ping
Cumming, Jared
Domalski, Martin
Gilbert, Eric
Hao, Jinsong
Kaelin, David
Stamford, Andrew
Taoka, Brandon
Walsh, Shawn
Duffy, Joseph
Nargund, Ravi
Weber, Ann
Orth, Peter
Wang, Hongwu
Caldwell, John
Scott, Jack
Yu, Younong
Simmons, Bryon
Xu, Yingju
Kuethe, Jeffrey
Ruck, Rebecca
Rindgen, Diane
Wang, Gary
Anstatt, Ryan
Mei, Hong
Pavlovsky, Anastasia
Cartwright, Mark
Smith, Brad
Michener, Maria
Agnihotri, Gautam
Chen, Xia
Gold, Steven
Hodgson, Robert
Hyde, Lynn
Kuvelkar, Reshmar
Lu, Sherry
Mayer-Ezell, Rosemary
Parker, Eric
Stahl, Lindsay
Werner, Bonnie
Zhang, Qi
Kennedy, Matthew
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
[37] Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays
Godemann, Robert
Madden, James
Kraemer, Joachim
Smith, Myron
Fritz, Ulrike
Hesterkamp, Thomas
Barker, John
Hoeppner, Sabine
Hallett, David
Cesura, Andrea
Ebneth, Andreas
Kemp, John
BIOCHEMISTRY, 2009, 48 (45) : 10743 - 10751
[38] Recent progress in the drug discovery of non-peptidic BACE1 inhibitors
Hamada, Yoshio
Kiso, Yoshiaki
EXPERT OPINION ON DRUG DISCOVERY, 2009, 4 (04) : 391 - 416
[39] Rational design of novel diaryl ether-linked benzimidazole derivatives as potent and selective BACE1 inhibitors
De, Tran Quang
Nguyen, Cuong Quoc
Dang, Quang Le
Thi, Nhu Y. Nguyen
Tuan, Nguyen Trong
Suh, Dong Hoon
Chu, Jeonghyun
Bepary, Sukumar
Lee, Ge Hyeong
Kang, Nam Sook
Cho, Heeyeong
Park, Woo Kyu
Lim, Hee-Jong
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 698
[40] Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors (vol 18, pg 3236, 2008)
Cumming, J. N.
Le, T. X.
Babu, S.
Carroll, C.
Chen, X.
Favreau, L.
Gaspari, P.
Guo, T.
Hobbs, D. W.
Huang, Y.
Iserloh, U.
Kennedy, M. E.
Kuvelkar, R.
Li, G.
Lowrie, J.
McHugh, N. A.
Ozgur, L.
Pan, J.
Parker, E. M.
Saionz, K.
Stamford, A. W.
Strickland, C.
Tadesse, D.
Voigt, J.
Wanga, L.
Wu, Y.
Zhang, L.
Zhang, Q.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (15) : 4447 - 4447

← 1 2 3 4 5 →