Single-cell gene regulation across aging tissues

被引：1
|
作者：
Lagger, Cyril [1 ]
de Magalhaes, Joao Pedro [1 ]
机构：
[1] Univ Liverpool, Inst Life Course & Med Sci, Integrat Genom Ageing Grp, Liverpool, England
来源：
NATURE AGING | 2022年 / 2卷 / 06期
关键词：
METAANALYSIS;
D O I：
10.1038/s43587-022-00238-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transcription factors can control cell identity and function in health and disease. However, how they do so during aging is incompletely explored. Maity and colleagues identify age-related changes in gene regulation by analyzing the expression patterns of transcription-factor target genes in single-cell transcriptomics data.
引用
收藏
页码：468 / 470
页数：3
相关论文
共 50 条
  • [41] CellWalker integrates single-cell and bulk data to resolve regulatory elements across cell types in complex tissues
    Pawel F. Przytycki
    Katherine S. Pollard
    Genome Biology, 22
  • [42] A single-cell atlas of the aging mouse ovary
    José V. V. Isola
    Sarah R. Ocañas
    Chase R. Hubbart
    Sunghwan Ko
    Samim Ali Mondal
    Jessica D. Hense
    Hannah N. C. Carter
    Augusto Schneider
    Susan Kovats
    José Alberola-Ila
    Willard M. Freeman
    Michael B. Stout
    Nature Aging, 2024, 4 : 145 - 162
  • [43] A single-cell atlas of the aging mouse ovary
    Isola, Jose V. V.
    Ocanas, Sarah R.
    Hubbart, Chase R.
    Ko, Sunghwan
    Mondal, Samim Ali
    Hense, Jessica D.
    Carter, Hannah N. C.
    Schneider, Augusto
    Kovats, Susan
    Alberola-Ila, Jose
    Freeman, Willard M.
    Stout, Michael B.
    NATURE AGING, 2024, 4 (01): : 145 - 162
  • [44] Decoding Aging Hallmarks at the Single-Cell Level
    Ma, Shuai
    Chi, Xu
    Cai, Yusheng
    Ji, Zhejun
    Wang, Si
    Ren, Jie
    Liu, Guang-Hui
    ANNUAL REVIEW OF BIOMEDICAL DATA SCIENCE, 2023, 6 : 129 - 152
  • [45] Investigation of human aging at the single-cell level
    Li, Yunjin
    Wang, Qixia
    Xuan, Yuan
    Zhao, Jian
    Li, Jin
    Tian, Yuncai
    Chen, Geng
    Tan, Fei
    AGEING RESEARCH REVIEWS, 2024, 101
  • [46] The generational scalability of single-cell replicative aging
    Liu, Ping
    Acar, Murat
    SCIENCE ADVANCES, 2018, 4 (01):
  • [47] Brain aging and rejuvenation at single-cell resolution
    Sun, Eric D.
    Nagvekar, Rahul
    Pogson, Angela N.
    Brunet, Anne
    NEURON, 2025, 113 (01) : 82 - 108
  • [48] Single-cell atlas of the aging mouse colon
    Sirvinskas, Dovydas
    Omrani, Omid
    Lu, Jing
    Rasa, Mahdi
    Krepelova, Anna
    Adam, Lisa
    Kaeppel, Sandra
    Sommer, Felix
    Neri, Francesco
    ISCIENCE, 2022, 25 (05)
  • [49] Cell type-specific genetic regulation of gene expression across human tissues
    Kim-Hellmuth, Sarah
    Aguet, Francois
    Oliva, Meritxell
    Munoz-Aguirre, Manuel
    Wucher, Valentin
    Kasela, Silva
    Castel, Stephane E.
    Hamel, Andrew R.
    Vinuela, Ana
    Roberts, Amy L.
    Mangul, Serghei
    Wen, Xiaoquan
    Wang, Gao
    Barbeira, Alvaro N.
    Garrido-Martin, Diego
    Nadel, Brian
    Zou, Yuxin
    Bonazzola, Rodrigo
    Quan, Jie
    Brown, Andrew
    Martinez-Perez, Angel
    Soria, Jose Manuel
    Getz, Gad
    Dermitzakis, Emmanouil T.
    Small, Kerrin S.
    Stephens, Matthew
    Xi, Hualin S.
    Im, Hae Kyung
    Guig, Roderic
    Segr, Ayellet, V
    Stranger, Barbara E.
    Ardlie, Kristin G.
    Lappalainen, Tuuli
    SCIENCE, 2020, 369 (6509) : 1332 - +
  • [50] Single-cell analyses of aging, inflammation and senescence
    Uyar, Bora
    Palmer, Daniel
    Kowald, Axel
    Escobar, Hugo Murua
    Barrantes, Israel
    Moeller, Steffen
    Akalin, Altuna
    Fuellen, Georg
    AGEING RESEARCH REVIEWS, 2020, 64
12345