Single-cell gene regulation across aging tissues

被引:1
|
作者
Lagger, Cyril [1 ]
de Magalhaes, Joao Pedro [1 ]
机构
[1] Univ Liverpool, Inst Life Course & Med Sci, Integrat Genom Ageing Grp, Liverpool, England
来源
NATURE AGING | 2022年 / 2卷 / 06期
关键词
METAANALYSIS;
D O I
10.1038/s43587-022-00238-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Transcription factors can control cell identity and function in health and disease. However, how they do so during aging is incompletely explored. Maity and colleagues identify age-related changes in gene regulation by analyzing the expression patterns of transcription-factor target genes in single-cell transcriptomics data.
引用
收藏
页码:468 / 470
页数:3
相关论文
共 50 条
  • [31] Spatial charting of single-cell transcriptomes in tissues
    Runmin Wei
    Siyuan He
    Shanshan Bai
    Emi Sei
    Min Hu
    Alastair Thompson
    Ken Chen
    Savitri Krishnamurthy
    Nicholas E. Navin
    Nature Biotechnology, 2022, 40 (8) : 1190 - 1199
  • [32] scHybridBERT: integrating gene regulation and cell graph for spatiotemporal dynamics in single-cell clustering
    Zhang, Wei
    Wu, Chenjun
    Xing, Feiyang
    Jiang, Mingfeng
    Zhang, Yixuan
    Liu, Qi
    Shi, Zhuoxing
    Dai, Qi
    BRIEFINGS IN BIOINFORMATICS, 2024, 25 (02)
  • [33] Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
    Stephen J. Clark
    Heather J. Lee
    Sébastien A. Smallwood
    Gavin Kelsey
    Wolf Reik
    Genome Biology, 17
  • [34] Spatial charting of single-cell transcriptomes in tissues
    Wei, Runmin
    He, Siyuan
    Bai, Shanshan
    Sei, Emi
    Hu, Min
    Thompson, Alastair
    Chen, Ken
    Krishnamurthy, Savitri
    Navin, Nicholas E.
    NATURE BIOTECHNOLOGY, 2022, 40 (08) : 1190 - +
  • [35] Microfluidic Devices for Investigating Stem Cell Gene Regulation via Single-Cell Analysis
    Zhong, Jiang F.
    Feng, Yun
    Taylor, Clive R.
    CURRENT MEDICINAL CHEMISTRY, 2008, 15 (28) : 2897 - 2900
  • [36] Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
    Clark, Stephen J.
    Lee, Heather J.
    Smallwood, Sebastien A.
    Kelsey, Gavin
    Reik, Wolf
    GENOME BIOLOGY, 2016, 17
  • [37] Widespread sex dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues
    Teefy, Bryan B.
    Lemus, Aaron J. J.
    Adler, Ari
    Xu, Alan
    Bhala, Rajyk
    Hsu, Katelyn
    Benayoun, Berenice A.
    CELL REPORTS, 2023, 42 (10):
  • [38] Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer
    Angarola, Brittany L.
    Sharma, Siddhartha
    Katiyar, Neerja
    Kang, Hyeon Gu
    Nehar-Belaid, Djamel
    Park, Sunghee
    Gott, Rachel
    Eryilmaz, Giray N.
    Labarge, Mark A.
    Palucka, Karolina
    Chuang, Jeffrey H.
    Korstanje, Ron
    Ucar, Duygu
    Anczukow, Olga
    NATURE AGING, 2025, 5 (01): : 122 - 143
  • [39] Single-cell analysis of λ immunity regulation
    Bæk, K
    Svenningsen, S
    Eisen, H
    Sneppen, K
    Brown, S
    JOURNAL OF MOLECULAR BIOLOGY, 2003, 334 (03) : 363 - 372
  • [40] CellWalker integrates single-cell and bulk data to resolve regulatory elements across cell types in complex tissues
    Przytycki, Pawel F.
    Pollard, Katherine S.
    GENOME BIOLOGY, 2021, 22 (01)