Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

被引:38
|
作者
Goda, Tadahiro [1 ]
Doi, Masao [2 ]
Umezaki, Yujiro [1 ]
Murai, Iori [2 ]
Shimatani, Hiroyuki [2 ]
Chu, Michelle L. [1 ]
Nguyen, Victoria H. [1 ]
Okamura, Hitoshi [2 ]
Hamada, Fumika N. [1 ,3 ,4 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Visual Syst Grp, Abrahamson Pediat Eye Inst, Div Pediat Ophthalmol, Cincinnati, OH 45229 USA
[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Syst Biol, Sakyo Ku, Kyoto 6068501, Japan
[3] Cincinnati Childrens Hosp Med Ctr, Div Dev Biol, Cincinnati, OH 45229 USA
[4] Univ Cincinnati, Coll Med, Dept Ophthalmol, Cincinnati, OH 45229 USA
基金
美国国家卫生研究院;
关键词
DH31R; Calcr; calcitonin receptor; circadian rhythm; body temperature rhythm; temperature preference rhythm; thermoregulation; CIRCADIAN CLOCK; SUPRACHIASMATIC NUCLEUS; SLEEP-WAKE; DROSOPHILA; PDF; NEURONS; NEUROPEPTIDE; ORGANIZATION; PHASE; NETWORK;
D O I
10.1101/gad.307884.117
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila. DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms.
引用
收藏
页码:140 / 155
页数:16
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