Role of estrogen in the etiology of peliosis hepatis

The aim of the study was to determine the relationship between estrogen and the development of peliosis hepatis. The experiment was conducted on female Wistar rats. Oestradiolum benzoicum was administered i.m. for 8 weeks in different doses. On the basis of the obtained data the authors claim that estrogen can be responsible for the development of vascular disorders described as peliosis hepatis. Furthermore, there is a relationship between the intensification of observed changes and the dose of the injected estrogen. An increased awareness of peliosis hepatis may become an important symptom for a pathologist, especially in patients at risk.