Have you seen this? Peliosis hepatis

被引:13
|
作者
Edwards, R
Colombo, T
Greaves, P
机构
[1] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England
[2] Ist Ric Farmacol Mario Negri, Milan, Italy
关键词
liver; peliosis; mouse; dexamethasone; melanoma; immunocytochemistry;
D O I
10.1080/01926230290105686
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Peliosis hepatis, characterized by the presence of blood- filled spaces within hepatic parenchyma, developed in C57B1 mice implanted subcutaneously with melanoma cells 23 days previously. The peliosis was associated with dilated hepatic sinusoids that were lined by prominent, proliferating endothelial cells. The development of peliosis hepatis was completely abrogated when melanoma growth was inhibited by administration of dexamethasone. These features support the concept that peliosis hepatis can be induced by a circulating tumor- derived endothelial growth factor such as vascular endothelial growth factor.
引用
收藏
页码:521 / 523
页数:3
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