Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

被引：46

作者：

Ergonul, O. ^{[1
]}

Aydin, M. ^{[2
]}

Azap, A. ^{[3
]}

Basaran, S. ^{[4
]}

Tekin, S. ^{[1
]}

Kaya, S. ^{[5
]}

Gulsun, S. ^{[5
]}

Yoruk, G. ^{[6
]}

Kursun, E. ^{[7
]}

Yesilkaya, A. ^{[8
]}

Simsek, F. ^{[9
]}

Yilmaz, E. ^{[10
]}

Bilgin, H. ^{[11
]}

Hatipoglu, C. ^{[12
]}

Cabadak, H. ^{[13
]}

Tezer, Y. ^{[13
]}

Togan, T. ^{[14
]}

Karaoglan, I. ^{[15
]}

Inan, A. ^{[16
]}

Engin, A. ^{[17
]}

Aliskan, H. E. ^{[7
]}

Yavuz, S. S. ^{[4
]}

Erdinc, S. ^{[12
]}

Mulazimoglu, L. ^{[11
]}

Azap, O. ^{[8
]}

Can, F. ^{[1
]}

Akalin, H. ^{[10
]}

Timurkaynak, F. ^{[2
]}

机构：

[1] Koc Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[2] Baskent Univ, Sch Med, Istanbul Hosp, Infect Dis & Clin Microbiol Dept, Etimesgut Ankara, Turkey

[3] Ankara Univ, Fac Med, Infect Dis & Clin Microbiol Dept, TR-06100 Ankara, Turkey

[4] Istanbul Univ, Istanbul Med Sch, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[5] Diyarbakir Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Diyarbakir, Turkey

[6] Istanbul Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[7] Baskent Univ, Sch Med, Adana Hosp, Infect Dis & Clin Microbiol Dept, Adana, Turkey

[8] Baskent Univ, Sch Med, Ankara Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[9] Okmeydani Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[10] Uludag Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Bursa, Turkey

[11] Marmara Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[12] Ankara Numune Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[13] Ankara Specialty Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[14] Baskent Univ, Sch Med, Konya Hosp, Infect Dis & Clin Microbiol Dept, Konya, Turkey

[15] Gaziantep Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Gaziantep, Turkey

[16] Haydarpasa Numune Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[17] Cumhuriyet Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Sivas, Turkey

来源：

JOURNAL OF HOSPITAL INFECTION | 2016年 / 94卷 / 04期

关键词：

Bloodstream; Gram-negative; Healthcare; IMPACT; ENTEROBACTERIACEAE; EPIDEMIOLOGY; BACTEREMIA; OUTCOMES;

D O I：

10.1016/j.jhin.2016.08.012

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality. (C) 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：381 / 385

页数：5

共 50 条

[41] Factors influencing antimicrobial resistance and outcome of Gram-negative bloodstream infections in children
Ivady, Balazs
Kenesei, Eva
Toth-Heyn, Peter
Kertesz, Gabriella
Tarkanyi, Klara
Kassa, Csaba
Ujhelyi, Eniko
Mikos, Borbala
Sapi, Erzsebet
Varga-Heier, Krisztina
Guoth, Gabor
Szabo, Dora
INFECTION, 2016, 44 (03) : 309 - 321
[42] Decision-support models for empiric antibiotic selection in Gram-negative bloodstream infections
MacFadden, D. R.
Coburn, B.
Shah, N.
Robicsek, A.
Savage, R.
Elligsen, M.
Daneman, N.
CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (01) : 108.e1 - 108.e7
[43] Factors influencing antimicrobial resistance and outcome of Gram-negative bloodstream infections in children
Balázs Ivády
Éva Kenesei
Péter Tóth-Heyn
Gabriella Kertész
Klára Tárkányi
Csaba Kassa
Enikő Ujhelyi
Borbála Mikos
Erzsébet Sápi
Krisztina Varga-Heier
Gábor Guóth
Dóra Szabó
Infection, 2016, 44 : 309 - 321
[44] Incidence and predictors of complications in Gram-negative bloodstream infection
Mondal, Utpal
Warren, Erin
Bookstaver, P. Brandon
Kohn, Joseph
Al-Hasan, Majdi N.
INFECTION, 2024, 52 (5) : 1725 - 1731
[45] Prevalence of Antimicrobial Resistance in Gram-Negative Bacteria Bloodstream Infections in Peru and Associated Outcomes: VIRAPERU Study
Krapp, Fiorella
Garcia, Coralith
Hinostroza, Noemi
Astocondor, Lizeth
Rondon, Claudia R.
Ingelbeen, Brecht
Alpaca-Salvador, Hugo A.
Amaro, Catherine
Ventura, Carla Aguado
Barco-Yaipen, Evelyn
Fernandez, Cesar Bocangel
Briones, Alexander
Burgos, Antonio
Campana, Rene
Castillo, Kelly
Castaneda-Sabogal, Alex
Coaquira, Angelica
Concha-Velasco, Fatima
Cuadros, Edwin Cuaresma
Chincha, Omayra
Diaz, Juan Carlos
Sipion, Roberto Diaz
Fernandez, Victor
Hueda-Zavaleta, Miguel
Lopez, Enrique
Valera-Krumdieck, Maria
Vasquez, Ruben
Torres, Ana Maria Vidaurre
Villegas-Chiroque, Miguel
Lopez, Favio Sarmiento
Zavaleta, Pedro Alberto Sullon
Chavez, Elizett Sierra
Peralta, Eduardo Paricahua
Cordova, Teresa Peralta
Pino-Duenas, Jimena Edith
Jacobs, Jan
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2023, 109 (05): : 1095 - 1106
[46] COMBINATION EMPIRIC THERAPY FOR GRAM-NEGATIVE HEALTHCARE-ASSOCIATED INFECTIONS: ADEQUACY OF AMINOGLYCOSIDES VERSUS FLUROQUINOLONES IN THE SETTING OF BETA-LACTAM RESISTANCE
Dortch, Marcus
Kauffmann, Rondi
Norris, Patrick
May, Addison
CRITICAL CARE MEDICINE, 2010, 38 (12) : U123 - U123
[47] ANTIBIOTIC RESISTANCE IN GRAM-NEGATIVE PERITONITIS
Borras, Merce
PERITONEAL DIALYSIS INTERNATIONAL, 2009, 29 (03): : 274 - 276
[48] The comparison of Gram-positive and Gram-negative healthcare-associated ventriculitis and meningitis in adults and children
Thomas Rogers
Kevin Sok
Timothy Erickson
Elizabeth Aguilera
Susan H. Wootton
Kristy O. Murray
Rodrigo Hasbun
Intensive Care Medicine, 2020, 46 : 128 - 131
[49] The comparison of Gram-positive and Gram-negative healthcare-associated ventriculitis and meningitis in adults and children
Rogers, Thomas
Sok, Kevin
Erickson, Timothy
Aguilera, Elizabeth
Wootton, Susan H.
Murray, Kristy O.
Hasbun, Rodrigo
INTENSIVE CARE MEDICINE, 2020, 46 (01) : 128 - 131
[50] New evidence for managing Gram-negative bloodstream infections
Nutman, Amir
Tellapragada, Chaitanya
Giske, Christian G.
Yahav, Dafna
CURRENT OPINION IN INFECTIOUS DISEASES, 2021, 34 (06) : 599 - 610

← 1 2 3 4 5 →