Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

被引：46

作者：

Ergonul, O. ^{[1
]}

Aydin, M. ^{[2
]}

Azap, A. ^{[3
]}

Basaran, S. ^{[4
]}

Tekin, S. ^{[1
]}

Kaya, S. ^{[5
]}

Gulsun, S. ^{[5
]}

Yoruk, G. ^{[6
]}

Kursun, E. ^{[7
]}

Yesilkaya, A. ^{[8
]}

Simsek, F. ^{[9
]}

Yilmaz, E. ^{[10
]}

Bilgin, H. ^{[11
]}

Hatipoglu, C. ^{[12
]}

Cabadak, H. ^{[13
]}

Tezer, Y. ^{[13
]}

Togan, T. ^{[14
]}

Karaoglan, I. ^{[15
]}

Inan, A. ^{[16
]}

Engin, A. ^{[17
]}

Aliskan, H. E. ^{[7
]}

Yavuz, S. S. ^{[4
]}

Erdinc, S. ^{[12
]}

Mulazimoglu, L. ^{[11
]}

Azap, O. ^{[8
]}

Can, F. ^{[1
]}

Akalin, H. ^{[10
]}

Timurkaynak, F. ^{[2
]}

机构：

[1] Koc Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[2] Baskent Univ, Sch Med, Istanbul Hosp, Infect Dis & Clin Microbiol Dept, Etimesgut Ankara, Turkey

[3] Ankara Univ, Fac Med, Infect Dis & Clin Microbiol Dept, TR-06100 Ankara, Turkey

[4] Istanbul Univ, Istanbul Med Sch, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[5] Diyarbakir Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Diyarbakir, Turkey

[6] Istanbul Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[7] Baskent Univ, Sch Med, Adana Hosp, Infect Dis & Clin Microbiol Dept, Adana, Turkey

[8] Baskent Univ, Sch Med, Ankara Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[9] Okmeydani Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[10] Uludag Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Bursa, Turkey

[11] Marmara Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[12] Ankara Numune Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[13] Ankara Specialty Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[14] Baskent Univ, Sch Med, Konya Hosp, Infect Dis & Clin Microbiol Dept, Konya, Turkey

[15] Gaziantep Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Gaziantep, Turkey

[16] Haydarpasa Numune Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[17] Cumhuriyet Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Sivas, Turkey

来源：

JOURNAL OF HOSPITAL INFECTION | 2016年 / 94卷 / 04期

关键词：

Bloodstream; Gram-negative; Healthcare; IMPACT; ENTEROBACTERIACEAE; EPIDEMIOLOGY; BACTEREMIA; OUTCOMES;

D O I：

10.1016/j.jhin.2016.08.012

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality. (C) 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：381 / 385

页数：5

共 50 条

[21] The effect of follow-up blood cultures on mortality and antibiotic use in gram-negative bloodstream infections
Mehmet Yildiz
Hamid Habibi
Fatma Betul Altin
Seref Kerem Corbacioglu
Hasan Selcuk Ozger
BMC Infectious Diseases, 23
[22] The effect of follow-up blood cultures on mortality and antibiotic use in gram-negative bloodstream infections
Yildiz, Mehmet
Habibi, Hamid
Altin, Fatma Betul
Corbacioglu, Seref Kerem
Ozger, Hasan Selcuk
BMC INFECTIOUS DISEASES, 2023, 23 (01)
[23] Study of the persistence of selected Gram-negative bacteria pathogens of healthcare-associated infections on hospital fabrics
Akinbobola, Ayorinde B.
Osunla, Ayodeji C.
Bello, Oluyemi M.
Ajayi, Olajide A.
AMERICAN JOURNAL OF INFECTION CONTROL, 2022, 50 (07) : 755 - 757
[24] Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections
Engers, Drew W.
Tamma, Pranita D.
Fiawoo, Suiyini
Fong, Karen
Jariwala, Ripal
Jenkins, Timothy C.
Kendall, Ronald E.
Lee, Jae Hyoung
McCreary, Erin K.
Patel, Payal K.
Shihadeh, Katherine C.
Slish, Judianne
Van Schooneveld, Trevor C.
Malani, Anurag N.
JAMA NETWORK OPEN, 2024, 7 (01)
[25] Prediction of Fluoroquinolone Resistance in Gram-Negative Bacteria Causing Bloodstream Infections
Dan, Seejil
Shah, Ansal
Justo, Julie Ann
Bookstaver, P. Brandon
Kohn, Joseph
Albrecht, Helmut
Al-Hasan, Majdi N.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (04) : 2265 - 2272
[26] Antibiotic appropriateness for Gram-negative bloodstream infections: impact of infectious disease consultation
Da Prat, Valentina
Galli, Laura
Cichero, Paola
Castiglioni, Barbara
Oltolini, Chiara
Tassan Din, Chiara
Andolina, Andrea
Bruzzesi, Elena
Poli, Andrea
Moro, Matteo
Mancini, Nicasio
Clementi, Massimo
Tresoldi, Moreno
Castagna, Antonella
Scarpellini, Paolo
Ripa, Marco
INFECTIOUS DISEASES, 2023, 55 (04) : 255 - 262
[27] Cefepime effectiveness in Gram-negative bloodstream infections
Al-Hasan, Majdi N.
Eckel-Passow, Jeanette E.
Baddour, Larry M.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (05) : 1156 - 1160
[28] Hemodialyzer Reuse and Gram-Negative Bloodstream Infections
Edens, Chris
Wong, Jacklyn
Lyman, Meghan
Rizzo, Kyle
Duc Nguyen
Blain, Michela
Horwich-Scholefield, Sam
Moulton-Meissner, Heather
Epson, Erin
Rosenberg, Jon
Patel, Priti R.
AMERICAN JOURNAL OF KIDNEY DISEASES, 2017, 69 (06) : 726 - 733
[29] Multidrug Resistance among Gram-Negative Pathogens That Caused Healthcare-Associated Infections Reported to the National Healthcare Safety Network, 2006-2008
Kallen, Alexander J.
Hidron, Alicia I.
Patel, Jean
Srinivasan, Arjun
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2010, 31 (05): : 528 - 531
[30] Fluoroquinolone use and resistance of Gram-negative bacteria causing healthcare-associated infections at a university hospital in Taiwan from 2000 to 2008
Cheng, Aristine
Tan, Che-Kim
Chu, Chen-Chen
Huang, Yu-Tsung
Liao, Chun-Hsing
Sheng, Wang-Huei
Hsueh, Po-Ren
JOURNAL OF INFECTION, 2012, 64 (06) : 618 - 620

← 1 2 3 4 5 →