Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

被引：46

作者：

Ergonul, O. ^{[1
]}

Aydin, M. ^{[2
]}

Azap, A. ^{[3
]}

Basaran, S. ^{[4
]}

Tekin, S. ^{[1
]}

Kaya, S. ^{[5
]}

Gulsun, S. ^{[5
]}

Yoruk, G. ^{[6
]}

Kursun, E. ^{[7
]}

Yesilkaya, A. ^{[8
]}

Simsek, F. ^{[9
]}

Yilmaz, E. ^{[10
]}

Bilgin, H. ^{[11
]}

Hatipoglu, C. ^{[12
]}

Cabadak, H. ^{[13
]}

Tezer, Y. ^{[13
]}

Togan, T. ^{[14
]}

Karaoglan, I. ^{[15
]}

Inan, A. ^{[16
]}

Engin, A. ^{[17
]}

Aliskan, H. E. ^{[7
]}

Yavuz, S. S. ^{[4
]}

Erdinc, S. ^{[12
]}

Mulazimoglu, L. ^{[11
]}

Azap, O. ^{[8
]}

Can, F. ^{[1
]}

Akalin, H. ^{[10
]}

Timurkaynak, F. ^{[2
]}

机构：

[1] Koc Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[2] Baskent Univ, Sch Med, Istanbul Hosp, Infect Dis & Clin Microbiol Dept, Etimesgut Ankara, Turkey

[3] Ankara Univ, Fac Med, Infect Dis & Clin Microbiol Dept, TR-06100 Ankara, Turkey

[4] Istanbul Univ, Istanbul Med Sch, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[5] Diyarbakir Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Diyarbakir, Turkey

[6] Istanbul Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[7] Baskent Univ, Sch Med, Adana Hosp, Infect Dis & Clin Microbiol Dept, Adana, Turkey

[8] Baskent Univ, Sch Med, Ankara Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[9] Okmeydani Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[10] Uludag Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Bursa, Turkey

[11] Marmara Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[12] Ankara Numune Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[13] Ankara Specialty Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey

[14] Baskent Univ, Sch Med, Konya Hosp, Infect Dis & Clin Microbiol Dept, Konya, Turkey

[15] Gaziantep Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Gaziantep, Turkey

[16] Haydarpasa Numune Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey

[17] Cumhuriyet Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Sivas, Turkey

来源：

JOURNAL OF HOSPITAL INFECTION | 2016年 / 94卷 / 04期

关键词：

Bloodstream; Gram-negative; Healthcare; IMPACT; ENTEROBACTERIACEAE; EPIDEMIOLOGY; BACTEREMIA; OUTCOMES;

D O I：

10.1016/j.jhin.2016.08.012

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality. (C) 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

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页码：381 / 385

页数：5

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