Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection

被引：18
|
作者：
Dunn, Diana M. [1 ]
Munger, Joshua [1 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14627 USA
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2020年 / 10卷
关键词：
cytomegalovirus; HCMV; calcium signaling; AMPK; cancer; oncomodulation; CA2+/CALMODULIN-DEPENDENT PROTEIN-KINASE; MUSCLE PHOSPHORYLASE-KINASE; LIGHT-CHAIN KINASE; LOCALIZED INHIBITOR; MYOGENIN EXPRESSION; MOLECULAR-CLONING; CANCER-PATIENTS; CALMODULIN; ACTIVATION; PROMOTES;
D O I：
10.3389/fcimb.2020.00384
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Calcium signaling and the AMP-activated protein kinase (AMPK) signaling networks broadly regulate numerous aspects of cell biology. Human Cytomegalovirus (HCMV) infection has been found to actively manipulate the calcium-AMPK signaling axis to support infection. Many HCMV genes have been linked to modulating calcium signaling, and HCMV infection has been found to be reliant on calcium signaling and AMPK activation. Here, we focus on the cell biology of calcium and AMPK signaling and what is currently known about how HCMV modulates these pathways to support HCMV infection and potentially contribute to oncomodulation.
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页数：14
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