Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

被引：32
|
作者：
Martinez, Michael [1 ]
Spitali, Mari [2 ]
Norrant, Edith L. [3 ]
Bracewell, Daniel G. [1 ]
机构：
[1] UCL, Dept Biochem Engn, London WC1E 6BT, England
[2] UCB Pharma, Slough SL1 4BG, Berks, England
[3] UCB Pharma, Brussels, Belgium
来源：
TRENDS IN BIOTECHNOLOGY | 2019年 / 37卷 / 03期
基金：
英国工程与自然科学研究理事会;
关键词：
CELL-CULTURE SUPERNATANT; RECOMBINANT ANTIBODIES; AFFINITY PRECIPITATION; POLYETHYLENE-GLYCOL; PURIFICATION; PROTEIN; REACTOR; CAPTURE;
D O I：
10.1016/j.tibtech.2018.09.001
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Advances in precipitation have demonstrated the capability of purifying therapeutic proteins such as antibodies from biological sources in a scalable and cost-effective manner. We discuss the latest developments in the unit operation for downstream processing applications and provide a perspective on exploring precipitation for bioprocess intensification.
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页码：237 / 241
页数：6
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