Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

被引：32

作者：

Martinez, Michael ^{[1
]}

Spitali, Mari ^{[2
]}

Norrant, Edith L. ^{[3
]}

Bracewell, Daniel G. ^{[1
]}

机构：

[1] UCL, Dept Biochem Engn, London WC1E 6BT, England

[2] UCB Pharma, Slough SL1 4BG, Berks, England

[3] UCB Pharma, Brussels, Belgium

来源：

TRENDS IN BIOTECHNOLOGY | 2019年 / 37卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

CELL-CULTURE SUPERNATANT; RECOMBINANT ANTIBODIES; AFFINITY PRECIPITATION; POLYETHYLENE-GLYCOL; PURIFICATION; PROTEIN; REACTOR; CAPTURE;

D O I：

10.1016/j.tibtech.2018.09.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Advances in precipitation have demonstrated the capability of purifying therapeutic proteins such as antibodies from biological sources in a scalable and cost-effective manner. We discuss the latest developments in the unit operation for downstream processing applications and provide a perspective on exploring precipitation for bioprocess intensification.

引用

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页码：237 / 241

页数：6

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