Successful treatment of cerebral aspergillosis with a high oral dose of itraconazole after excisional surgery

被引：25

作者：

Imai, T ^{[1
]}

Yamamoto, T ^{[1
]}

Tanaka, S ^{[1
]}

Kashiwagi, M ^{[1
]}

Chiba, S ^{[1
]}

Matsumoto, H ^{[1
]}

Uede, T ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Neurol, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

来源：

INTERNAL MEDICINE | 1999年 / 38卷 / 10期

关键词：

fungus infection; sphenoid sinus; brain abscess; MRI;

D O I：

10.2169/internalmedicine.38.829

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of cerebral aspergillosis which originated from the sphenoid sinus, and involved a progressive decrease of visual acuity, The neurological signs indicated a cavernous sinus invasion. After extensive intracranial surgery we treated the residual aspergillosis with a high oral dose of itraconazole (800 mg/d for 4 months, followed by 400 mg/d for 5 months). The neurological impairments of the patient gradually subsided with the resolution of the fungal lesion shown on MRI. The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults).

引用

页码：829 / 832

页数：4

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